The New York Giants and Buffalo Bills are slated to meet up on Sunday Night Football for Week 6 of the season. The New York Giants come into the game with a 1-4 record.
The Giants have looked poor most of the season, with their lone win coming late in the game from behind against Arizona. The Giants are in last place in the NFC East.
For Buffalo, they are in second place in the AFC East behind the Miami Dolphins. A week after beating the Dolphins, the Bills went to London and got beat by Jacksonville. The Buffalo Bills are -15 at home in this game on Sunday Night Football.
MyBookie offers the game prediction plus NFL lines, analysis, along with a free pick for New York Giants versus the Buffalo Bills which are playing on Week 6 of the season.
SNF Giants vs Bills Betting Prediction: Get Your NFL Odds for the Game | MyBookie NFL Week 6 Regular Season Preview
New York Giants vs Buffalo Bills | NFL Week 6 Sunday Night Football
ATS Odds: Bills -15
Money line Odds: Giants +750 / Bills -1408
Over/Under Odds: 44
Sunday, October 15th, 2023 at 8:20 pm ET | NBC
Highmark Stadium, Orchard Park, NY
Allen and Company Ready to Bounce Back
The Buffalo Bills are going to look to bounce back following their 25-20 loss to the Jaguars. While Allen threw for over 300 yards, they could not quit shooting themselves in the foot, and they struggled to get into the end zone.
On the season, Buffalo is scoring 31.8 points per game, which ranks third in all of the National Football League. The passing game is picking up 274.2 yards per game, while they are rushing for more than 116 per game.
The defense is allowing just 16 points per game. In the Bills’ two losses this season, they allowed 23.5 per game. Back to the offense for Buffalo, Allen has tossed for 11 touchdowns but also five interceptions on the season.
Stefon Diggs has been his top target this season. Diggs has 39 receptions for 520 yards and five touchdowns. Gabe Davis is next on the team with four touchdown receptions.
The Bills have a trip to New England next week and then a Thursday Night Football home game against Tampa Bay to wrap up October.
Giants Struggles have Been Mighty
The New York Giants have not only struggled to find wins but are now the walking wounded. Daniel Jones, Darren Waller, and Saquan Barkley are all listed as questionable with injuries in that game.
That is a big chunk of the offense. That would leave Tyrod Taylor back as the starting quarterback, with Matt Brieda checking in as the starting running back again.
The Giants are the second worst scoring team in all of the National Football League. New York is scoring just 12.4 points per game. Barkley has been able to play in just two games this season, with 29 carries, 114 yards and a score. The top offensive threat for the Giants is Waller, but despite 23 receptions and 239 yards, he has yet to score a touchdown.
New York will play this game at Buffalo and then go home and host the Washington Commanders in a divisional rivalry game. The following week, another rivalry game will be played at home.
This time, it’s the New York Jets. The Giants will then start the month of November with back-to-back road games. The Giants are at the Raiders on November 5th and the Cowboys on November 12th.
SNF Giants vs Bills Betting Prediction | Buffalo Wins Running Away
Too much Josh Allen. Too much Buffalo defense and too many question marks for the New York Giants. This just does not seem like a season to remember for the New York Giants. Things have not and are not going well.
Look for the Giants to struggle again while the Buffalo Bills find a groove here. The Bills are going to win this one with ease.
When you are betting on this game, take the Buffalo Bills -15 over the New York Giants on Sunday Night Football.
NFL Week 6 Pick: Buffalo Bills -15 | Bet Giants vs Bills
MyBookie Betting Lines for the Game
New York Giants Last 5
| Date | OPP | Result |
|---|---|---|
| 10/2/23 | @ NYG | W24-3 |
| 9/24/23 | vs CAR | W37-27 |
| 1/17/23 | @ DET | W37-31 OT |
| 9/10/23 | vs LAR | L30-13 |
| 8/26/23 | @ GB | L19-15 |
New York Giants Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Daniel Jones QB | Out | Oct 13 |
| Azeez Ojulari LB | Out | Oct 13 |
| John Michael Schmitz Jr. C | Out | Oct 13 |
| Matt Peart OT | Out | Oct 13 |
| Andrew Thomas OT | Out | Oct 13 |
NFC East Standings | New York Giants
| Team | W | L | T | Strk |
|---|---|---|---|---|
| Philadelphia Eagles | 5 | 0 | 0 | W5 |
| Dallas Cowboys | 3 | 2 | 0 | L1 |
| Washington Commanders | 2 | 3 | 0 | L3 |
| New York Giants | 1 | 4 | 0 | L3 |
Buffalo Bills Last 5
| Date | OPP | Result |
|---|---|---|
| 10/8/23 | @ ARI | W34-20 |
| 10/1/23 | @ TEN | L27-3 |
| 9/25/23 | vs LAR | W19-16 |
| 1/17/23 | vs BAL | L27-24 |
| 9/10/23 | @ CLE | L24-3 |
Buffalo Bills Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Matt Milano LB | Questionable | Oct 13 |
| DaQuan Jones DT | Questionable | Oct 13 |
| Baylon Spector LB | Questionable | Oct 13 |
| Dawson Knox TE | Questionable | Oct 13 |
| Dalton Kincaid TE | Questionable | Oct 13 |
AFC East Standings | Buffalo Bills
| Team | W | L | T | Strk |
|---|---|---|---|---|
| Miami Dolphins | 4 | 1 | 0 | W1 |
| Buffalo Bills | 3 | 2 | 0 | L1 |
| New York Jets | 2 | 3 | 0 | W1 |
| New England Patriots | 1 | 4 | 0 | L2 |
New York Giants at Buffalo Bills Betting Trends
- Over their last five meetings, New York has collected three wins versus Buffalo.
- Over their last five head-to-head matchups, New York has scored 110 points, while Buffalo has tallied 107.
- Against the spread, Buffalo is 3-2-0 this year.
- Buffalo games this year have hit the over on two of five set point totals (40%).
- When playing as moneyline favorites, the Bills are 3-2, earning a victory 60% of the time.
- Buffalo has not yet played as a moneyline favorite of -900 or shorter.
- The implied probability in this matchup, considering the moneyline, gives the Bills a 90.0% chance to win.
The following NFL betting odds are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
The following NFL betting lines are based on MyBookie Sportsbook.
| Teams | Odds |
|---|---|
| San Francisco 49ers | +550 |
| Kansas City Chiefs | +700 |
| Baltimore Ravens | +800 |
| Buffalo Bills | +1000 |
| Detroit Lions+1200 | |
| Cincinnati Bengals | +1300 |
| Dallas Cowboys | +1600 |
| Philadelphia Eagles | +1800 |
| Miami Dolphins | +2000 |
| Green Bay Packers | +2200 |
| Houston Texans | +2200 |
| LA Chargers | +2500 |
| New York Jets | +2500 |
| Jacksonville Jaguars | +3500 |
| Los Angeles Rams | +3500 |
| Cleveland Browns | +4000 |
| Minnesota Vikings | +4000 |
| Atlanta Falcons | +5000 |
| Chicago Bears | +5000 |
| Indianapolis Colts | +5000 |
| Denver Broncos | +7500 |
| Las Vegas Raiders | +7500 |
| New Orleans Saints | +7500 |
| Pittsburgh Steelers | +7500 |
| Seattle Seahawks | +7500 |
| Tampa Bay Buccaneers | +7500 |
| Arizona Cardinals | +10000 |
| New England Patriots | +15000 |
| New York Giants | +15000 |
| Tennessee Titans | +15000 |
| Washington Commanders | +15000 |
| Carolina Panthers | +25000 |
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