2022 College Football ATS Betting Picks for the Top Weekend Games of Week 1

We just had our first weekend of the new college football season this past weekend, but that is not regarded as the official start of the season. Those games fall under what is now referred to as Week 0, but we get out first full week of action starting on Thursday. There are some absolutely massive games on the Week 1 schedule, including the defending champion Georgia Bulldogs opening their season with a tough one against the Oregon Ducks. As we all know, it’s tough to make accurate predictions in the early going, but we are going to do our best to see if we can deliver some winners this weekend. We are going to start off by making some NCAA Football Betting picks against the spread, so let’s jump right in.

NCAAF Week 1 Against the Spread Betting Picks | 2022 College Football Analysis

Central Michigan Chippewas at Oklahoma State Cowboys (-20 ½)

I am always a little wary about playing the games with the larger spreads, but we often get a lot of that in Week 1, when the Power 5 teams face lesser-known foes in games that very often among to nothing more than a warm-up. We have one of those on Thursday night, with CMU going on the road to face Oklahoma State. The Cowboys have a reputation for putting up big offense, so you would certainly like them to get some points on the board here. They are 12-3-1 ATS in their last 16 games overall, so they certainly seem like a very decent bet.

Virginia Tech Hokies (-8 ½) at Old Dominion Monarchs

For this one, we are making the jump to Friday night, with Virginia Tech set to get their season started on the road against Old Dominion. I do have to say that this one might fall on the riskier side of things based on the ATS trends from both of these teams. Old Dominion has covered the spread in each of their last 4 games versus teams from the ACC, while Virginia Tech is just 3-9 ATS in their last 12 road games. Despite all of that, I think the spread here is manageable, which is why I am taking the Hokies to cover.

Colorado State Rams at Michigan Wolverines (-27)

The Wolverines are coming off one of their best seasons in recent history, winning the Big Ten Championship and making it to the playoffs, where they ended up losing to Georgia, the eventual champions. They are looking to have a similar type of season and get started with a game that should be on the straightforward side of things. It’s another big point spread, but the Rams have managed to cover the spread just 3 times in their last 10 games away from home. On the flipside, the Michigan Wolverines are 6-2 ATS in their last 8 played at home. I am on Michigan to cover in this one.

Miami-Ohio Redhawks at Kentucky Wildcats (-17)

Kentucky had a very good season in 2021, winning their opening 6 games before running into Georgia. They probably still have a way to go to be a serious contender in the SEC East, but they should have a similar type of season as last year. The Wildcats are 3-1-1 ATS in their last 5 home games, but they are a much more impressive 9-2 ATS in their last 11 games versus teams from the MAC. I think that Kentucky looks like a good bet in this one.


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