Bills vs Chiefs Odds, Pick, and Predictions for Week 6 of the 2022 Season

Bills vs Chiefs Odds, Pick, and Predictions for Week 6 of the 2022 Season

One of the top rivalries in the AFC resumes on Sunday when the Buffalo Bills tackle the Kansas City Chiefs. The Bills travel to KC to battle their nemesis for the conference’s 1-seed. Will Josh Allen and his fellas get it done at GEHA Field at Arrowhead? Or will Patrick Mahomes and his mates pull off the home upset victory? Check out NFL Odds, analysis, and a free pick for Bills at Chiefs.

NFL Week 6 Betting Preview for Buffalo Bills versus Kansas City Chiefs

Buffalo Bills at Kansas Odds and Match Info

  • When: Sunday, Oct. 16 at 4:25 pm ET 
  • Where: GEHA Field at Arrowhead Stadium, Kansas City, MO
  • TV / Streaming: CBS / Paramount
  • ATS Odds: Buffalo -2.5
  • Moneyline Odds: Buffalo -140 / Kansas +114   
  • Over/Under Odds: 39

Why bet on Buffalo versus Kansas City?

The Bills have a single blemish on their record, a 20-19 loss to NFC East rival Miami. Buffalo had a chance to win the game, but fell short on a final drive. Since the loss, the Bills have beaten the Baltimore Ravens on the road and stomped the Pittsburgh Steelers 38-3. Josh Allen is an unstoppable force while Kansas City played in a tough game this past Monday night versus the Raiders.

Buffalo Bills Offensive Averages

  • Total Yards: 440.5
  • Passing Yards: 324.0
  • Rushing Yards: 116.4
  • Points Scored: 30.4
  • Turnovers: 9

Buffalo Bills Defensive Averages

  • Total Yards: 260.4
  • Passing Yards: 182.6
  • Rushing Yards: 77.8
  • Points Scored: 12.2
  • Takeaways: 9

Why bet on Kansas City versus Buffalo?

Yes, Kansas City played in a tough game against the Raiders, but the Chiefs prevailed 30-29. One of the reasons for the close contest may have been the Chiefs looking ahead to this game. Kansas City knows that beating Buffalo could hand them the AFC’s top seed. Patrick Mahomes should have a much better game versus a Buffalo defense that doesn’t always play it’s best. 

Kansas City Chiefs Offensive Averages

  • Total Yards: 381.4
  • Passing Yards: 267.2
  • Rushing Yards: 114.2
  • Points Scored: 31.8
  • Turnovers: 4

Kansas City Chiefs Defensive Averages

  • Total Yards: 339.2
  • Passing Yards: 255.6
  • Rushing Yards: 83.6
  • Points Scored: 25.0
  • Takeaways: 3

Bills at Chiefs Relevant Trends

  • Bills are 7-2-2 ATS in their last 11 games
  • Buffalo is 2-6 ATS in the last 8 meetings
  • Under is 4-1 in the Bills’ last 5 games
  • Chiefs are 0-4 ATS in their last 4 versus the AFC
  • Kansas City is 7-3 ATS versus a team with a winning record
  • Over is 8-2 in the Chiefs last 10 games on grass

Buffalo Bills at Kansas City Chiefs Final Betting Prediction

Stats and trends don’t mean much in this contest. For example, the Bills are 7-2-2 against the spread in their last 11 but 2-6 against the spread in the last 8 meetings. So does that mean the Bills win but only win by 2? Or does it mean Buffalo wins by 3?

The best thing to do is look at last season’s playoff game and try to get an idea of what will happen on Sunday. In the classic last match, the Chiefs beat the Bills 42-36 in overtime.

Kansas City turned it on in he fourth quarter, outscoring Buffalo 3 touchdowns to 2, which means KC’s defense stepped it up when they had to while Buffalo’s defense may have tired.

When it comes to this game, both teams have injuries on the defensive side of the ball. So we should expect another track meet. That doesn’t bode well for the Chiefs.

Why? Mahome’s top wide receiver targets aren’t one-hundred percent. Marquez Valdes-Scantling and Mecole Hardman are suffering from nagging injuries.

In the rematch, Allen and his offense has the edge over Mahomes and his offense. The Bills prevail with a win and cover.  

NFL Week 6 Pick: Buffalo Bills -2.5 


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