2023 NFL Week 1 Must Bet Games

2023 NFL Week 1 Must Bet Games

The only thing more fun than betting on NFL games is talking about which NFL games to bet. And it doesn’t matter how many weeks we have to wait until those games are played.

See below for NFL betting lines and analysis for all the games happening on Week 1 of the 2023 season.


NFL Week 1 Must Bet Games | MyBookie NFL Preview

NFL Week 1: September 7-11, 2023


Detroit Lions at Kansas City Chiefs | Thursday Night Football

NFL Odds: Lions +7, Chiefs -7 / Lions +240, Chiefs -309 / O/U 54
When: Thursday, September 7, 2023 at 8:20 pm ET
Where: GEHA Field at Arrowhead Stadium, Kansas City, MO 

Most of the football world is bullish on the Detroit Lions this season in the NFC North. But this is Andy Reid coming off the biggest bye of the season (he’s 9-1 in Week 1 with the Chiefs), and this is Patrick Mahomes in September. In 16 career September starts, Mahomes has 5,101 passing yards and 49 touchdowns to just four interceptions.

This game is also the kickoff to the NFL season on Thursday night, and as the Chiefs hang their new Super Bowl banner, the crowd will be electric.

The Lions needed this game to be in October, when the Chiefs tend to have a midseason swoon, and the crowd is restless. Instead, they get the Chiefs at the absolute worst time, and Kansas City is giving up less than a touchdown. Mahomes and the Chiefs feast.

NFL Betting | Bet Lions vs. Chiefs
MyBookie Betting Lines for the Game


San Francisco 49ers at Pittsburgh Steelers

NFL Odds: 49ers -3, Steelers +3 / 49ers -160, Steelers +139 / O/U 41.5
When: Sunday, September 10, 2023, 2023 at 1:00 pm ET
Where: Acrisure Stadium, Pittsburgh, PA 

The 49ers were the second-best team in the NFC last season, and they might be that good again. But with an unsettled quarterback position heading into the season, starting on the road at Pittsburgh is a tough task.

Pittsburgh finished 2022 strong, winning four straight to end the year and six of their last seven. The growth we saw from quarterback Kenny Pickett in November and December will be even more noticeable in 2023, and if you get a chance to get points from the Steelers at home on the opening week, take them.

Remember, in each of the last two season openers, Pittsburgh beat Buffalo and Cincinnati as big underdogs. Take the Steelers and the points.

NFL Betting | Bet 49ers vs. Steelers
MyBookie Betting Lines for the Game


Green Bay Packers at Chicago Bears

NFL Odds: Packers +2.5, Bears -2.5 / Packers +111, Bears -135 / O/U 44.5
When: Sunday, September 10, 2023, 2023 at 4:25 pm ET
Where: Soldier Field, Chicago, IL 

It’s a new era in the storied Packers-Bears rivalry. Gone is Aaron Rodgers, the self-proclaimed “owner” of the Bears. And backing up Rodgers’ boasts was his gaudy 23-5 against Chicago.

He is now in New York, and he’s taken his dominance with him. And after a really great offseason in Chicago, the Bears are actually picked to finish ahead of Green Bay in the NFC North. With a point spread of less than a field goal, bet the Bears.

NFL Betting | Bet Packers vs. Bears
MyBookie Betting Lines for the Game


Los Angeles Rams at Seattle Seahawks

NFL Odds: Rams +6, Seahawks -6 / Rams +196, Seahawks -248 / O/U 46.5
When: Sunday, September 10, 2023, 2023 at 4:25 pm ET
Where: Lumen Field, Seattle, WA 

The Los Angeles Ram’s biggest move this offseason was trading away their best defensive back. The Seattle Seahawks added Jaxon Smith-Njigba to an already loaded offense, and this team is primed to make another trip to the playoffs.

Add in rookie cornerback Devin Witherspoon to one of the best young secondaries in the NFL, and this game might end up being a mismatch. Seattle looks like a 10 or 11 win team, and the Rams might struggle to get to six wins.

At home, giving up just 5.5 points, a bet on Geno Smith and the high-powered offense of Seattle seems like an obvious bet.

NFL Betting | Bet Rams vs. Seahawks
MyBookie Betting Lines for the Game


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