A pair of NFC West teams will meet up on Sunday in Week 4 of the National Football League season. The Arizona Cardinals will take on the unbeaten San Francisco 49ers.
The Cardinals are 1-2, following back-to-back losses to start the season; they beat the Dallas Cowboys in Week 3 in the week’s biggest upset. Arizona is tied with the Rams for third place in the NFC West.
For the 49ers, they are perfect so far this season. The 49ers are one of three remaining teams without a loss. San Francisco is coming off their Thursday Night Football win over the New York Giants in Week 3.
The San Francisco 49ers are -14 over the Arizona Cardinals in this game. MyBookie has the betting prediction for this NFC West matchup plus NFL betting lines, analysis, and free pick for Arizona Cardinals versus the San Francisco 49ers on Week 4 of the season..
Cardinals vs 49ers and Betting Prediction for this Week 4 NFC West Matchup | MyBookie NFL Week 4 Regular Season Preview
Arizona Cardinals vs San Francisco 49ers | NFL Week 4 Late Afternoon Football
ATS 49ers: Cardinals -14
Money line 49ers: Cardinals -625/ 49ers +950
Over/Under 49ers: 44
Sunday, October 1st, 2023 at 4:25 pm ET | FOX
Levi’s Stadium, Santa Clara, CA
Cardinals Surging?
It will be interesting to see if the Arizona Cardinals can build off that Week 3 win. Some predicted this team would not win a single game all season.
Arizona could be 2-1 after they blew a big lead against the Giants in Week 2. The Cardinals have scored 72 points and allowed 67 on the season, so they are playing competitive football.
Joshua Dobbs is doing his job as the signal caller for Arizona. Dobbs has just two passing touchdowns, but they need to move the chains and take care of the football.
James Connor has been solid for Arizona, shy of 90 yards per game on the ground. The Cardinals are doing their damage on offense with the rushing attack. They are averaging 156.3 yards per game for Jonathan Gannon.
The Cardinals are on the road for this game before returning home for Week 5. They will welcome Joe Burrow and his Cincinnati Bengals to town in that game. Following that, Arizona has back-to-back divisional games on the road. The Cardinals will take on the Rams and Seahawks.
Run Away Train, Known as 49ers
The San Francisco 49ers look like a runaway train with no one stopping them. Kyle Shanahan has some of the best offensive weapons in the league.
San Francisco has opened the season with 30 points per game. The 49ers have scored 30 points in each of the three games this season. The defense has done its part, holding opponents to 14 points per game.
On the offensive side, Christian McCaffrey is the name everyone wants to discuss. The running back has 353 yards on the ground and three touchdowns while carrying his load in receiving. Deebo Samuel is the top receiver for the 49ers with 247 yards and a touchdown.
The 49ers have been pleased with former Iowa State signal caller Brock Purdy as he progresses in the league. Purdy has 736 yards and four touchdowns.
The 49ers are playing their second of three straight home games. Next week, the 49ers will be on Sunday Night Football as they host the Dallas Cowboys. After that, the 49ers are on the road at the Cleveland Browns and Minnesota Vikings.
SNF Cardinals vs 49ers Betting Prediction | Underdog on the Road?
It’s hard to bet on a team with touchdowns in the National Football League. The 49ers would be one of those teams we would like to do it with.
But too many things can happen in this league, so that we will take the underdog. Arizona gets into the end zone several times and avoids the disaster.
In the end, they cover the +14 spread. The final bet for this game is the Arizona Cardinals +14. The final score prediction for this affair on Sunday is the San Francisco 49ers 27-17 over the Arizona Cardinals.
NFL Week 4 SNF Pick: ATS Cardinals +14 | Bet Cardinals vs 49ers
MyBookie Betting Lines for the Game
Arizona Cardinals Last 5
| Date | OPP | Result |
|---|---|---|
| 9/24/23 | vs DAL | W28-16 |
| 9/17/23 | vs NYG | L31-28 |
| 9/10/23 | @ WSH | L20-16 |
| 8/26/23 | @ MIN | W18-17 |
| 8/19/23 | vs KC | L38-10 |
Arizona Cardinals Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Josh Woods LB | Questionable | Sep 26 |
| James Conner RB | Questionable | Sep 27 |
| Jonathan Ledbetter DE | Questionable | Sep 27 |
| Krys Barnes LB | Questionable | Sep 27 |
NFC West Standings
| Team | W | L | T | Strk |
|---|---|---|---|---|
| San Francisco 49ers | 3 | 0 | 0 | W3 |
| Seattle Seahawks | 2 | 1 | 0 | W2 |
| Los Angeles Rams | 1 | 2 | 0 | L2 |
| Arizona Cardinals | 1 | 2 | 0 | W1 |
San Francisco 49ers Last 5
| Date | OPP | Result |
|---|---|---|
| 9/24/23 | vs NYG | W30-12 |
| 9/17/23 | @ LAR | W30-23 |
| 9/10/23 | @ WSH | W30-7 |
| 8/25/23 | vs MIN | L23-12 |
| 8/19/23 | vs KC | W21-20 |
San Francisco 49ers Injury Report
| Name | Position | Status | DATE |
|---|---|---|
| Ambry Thomas CB | Questionable | Sep 26 |
| Deebo Samuel WR | Questionable | Sep 27 |
| Brandon Aiyuk WR | Questionable | Sep 27 |
| Jauan Jennings WR | Questionable | Sep 27 |
| Dre Greenlaw LB | Questionable | Sep 27 |
NFL Odds to Win
Arizona Cardinals
Super Bowl Odds to Win: +32000
NFC Conference Odds to Win: +16000
San Francisco 49ers
Super Bowl Odds to Win: +570
NFC Conference Odds to Win: +234
Arizona Cardinals at San Francisco 49ers Betting Trends
- In the last 1 of 2 Away games, the San Francisco 49ers have not hit the Moneyline bet (ROI: -38.9%)
- The San Francisco 49ers have hit the Moneyline in 3 of their last 4 games (ROI: 6.6%)
- The San Francisco 49ers have hit the Moneyline in 2 of their last 2 Home games (ROI: 52.1%)
- The Arizona Cardinals have not hit the Moneyline in 3 of their last 4 Home games (ROI: -57.8%)
- In the last 2 of 3 Away games, the Arizona Cardinals have not hit the Moneyline bet (ROI: -35.8%)
- The Arizona Cardinals have not hit the Moneyline in 5 of their last 7 games (ROI: -48.3%)
- The San Francisco 49ers have covered the Point Spread in 2 of their last 2 Home games (ROI: 90.5%)
- In the last 1 of 2 Away games, the San Francisco 49ers have not hit the Point Spread bet (ROI: -3.7%)
- In the last 3 of 4 games, the San Francisco 49ers have hit the Point Spread bet (ROI: 43.4%)
- In the last 2 of 4 Home games, the Arizona Cardinals have not hit the Point Spread bet (ROI: -3.0%)
- The Arizona Cardinals have not covered the Point Spread in 2 of their last 3 Away games (ROI: -36.4%)
- The Arizona Cardinals have not covered the Point Spread in 4 of their last 7 games (ROI: -17.3%)
The following NFL betting 49ers are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
The following NFL betting lines are based on MyBookie Sportsbook.
| Teams | Odds |
|---|---|
| Eagles | +680 |
| Ravens | +710 |
| Bills | +710 |
| Chiefs | +750 |
| Teams | Odds |
|---|---|
| Lions | +930 |
| 49ers | +1800 |
| Commanders | +1850 |
| Bengals | +1950 |
| Teams | Odds |
|---|---|
| Rams | +2100 |
| Packers | +2200 |
| Chargers | +2600 |
| Broncos | +2682 |
| Teams | Odds |
|---|---|
| Vikings | +2900 |
| Bucaneers | +3100 |
| Texans | +3400 |
| Bears | +3800 |
| Teams | Odds |
|---|---|
| Steelers | +4400 |
| Cowboys | +5000 |
| Cardinals | +5800 |
| Seahawks | +6000 |
| Teams | Odds |
|---|---|
| Patriots | +6400 |
| Dolphins | +6800 |
| Cowboys | +5000 |
| Falcons | +7000 |
| Teams | Odds |
|---|---|
| Jaguars | +8000 |
| Colts | +10000 |
| Raiders | +11000 |
| Panthers | +12000 |
| Teams | Odds |
|---|---|
| Jets | +18000 |
| Titans | +20000 |
| Giants | +20000 |
| Browns | +22000 |
Enjoy the game, and best of luck with all your NFL Betting for Week 4!
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