Kickoff Your Bets with These Must-Win NFL Week 1 Bets

 

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The only thing more fun than betting on NFL games is talking about which NFL games to bet. And it doesn’t matter how many weeks we have to wait until those games are played.

See below for NFL betting lines and analysis for all the games happening on Week 1 of the 2023 season.

NFL Week 1 Must Bet Games | MyBookie NFL Preview

NFL Week 1: September 7-11, 2023

Detroit Lions at Kansas City Chiefs | Thursday Night Football

NFL Odds: Lions +7, Chiefs -7 / Lions +240, Chiefs -309 / O/U 54
When: Thursday, September 7, 2023 at 8:20 pm ET
Where: GEHA Field at Arrowhead Stadium, Kansas City, MO

Most of the football world is bullish on the Detroit Lions this season in the NFC North. But this is Andy Reid coming off the biggest bye of the season (he’s 9-1 in Week 1 with the Chiefs), and this is Patrick Mahomes in September. In 16 career September starts, Mahomes has 5,101 passing yards and 49 touchdowns to just four interceptions.

This game is also the kickoff to the NFL season on Thursday night, and as the Chiefs hang their new Super Bowl banner, the crowd will be electric.

The Lions needed this game to be in October, when the Chiefs tend to have a midseason swoon, and the crowd is restless. Instead, they get the Chiefs at the absolute worst time, and Kansas City is giving up less than a touchdown. Mahomes and the Chiefs feast.

NFL Betting | Bet Lions vs. Chiefs
MyBookie Betting Lines for the Game

San Francisco 49ers at Pittsburgh Steelers

NFL Odds: 49ers -3, Steelers +3 / 49ers -160, Steelers +139 / O/U 41.5
When: Sunday, September 10, 2023, 2023 at 1:00 pm ET
Where: Acrisure Stadium, Pittsburgh, PA

The 49ers were the second-best team in the NFC last season, and they might be that good again. But with an unsettled quarterback position heading into the season, starting on the road at Pittsburgh is a tough task.

Pittsburgh finished 2022 strong, winning four straight to end the year and six of their last seven. The growth we saw from quarterback Kenny Pickett in November and December will be even more noticeable in 2023, and if you get a chance to get points from the Steelers at home on the opening week, take them.

Remember, in each of the last two season openers, Pittsburgh beat Buffalo and Cincinnati as big underdogs. Take the Steelers and the points.

NFL Betting | Bet 49ers vs. Steelers
MyBookie Betting Lines for the Game

Green Bay Packers at Chicago Bears

NFL Odds: Packers +2.5, Bears -2.5 / Packers +111, Bears -135 / O/U 44.5
When: Sunday, September 10, 2023, 2023 at 4:25 pm ET
Where: Soldier Field, Chicago, IL

It’s a new era in the storied Packers-Bears rivalry. Gone is Aaron Rodgers, the self-proclaimed “owner” of the Bears. And backing up Rodgers’ boasts was his gaudy 23-5 against Chicago.

He is now in New York, and he’s taken his dominance with him. And after a really great offseason in Chicago, the Bears are actually picked to finish ahead of Green Bay in the NFC North. With a point spread of less than a field goal, bet the Bears.

NFL Betting | Bet Packers vs. Bears
MyBookie Betting Lines for the Game

Los Angeles Rams at Seattle Seahawks

NFL Odds: Rams +6, Seahawks -6 / Rams +196, Seahawks -248 / O/U 46.5
When: Sunday, September 10, 2023, 2023 at 4:25 pm ET
Where: Lumen Field, Seattle, WA

The Los Angeles Ram’s biggest move this offseason was trading away their best defensive back. The Seattle Seahawks added Jaxon Smith-Njigba to an already loaded offense, and this team is primed to make another trip to the playoffs.

Add in rookie cornerback Devin Witherspoon to one of the best young secondaries in the NFL, and this game might end up being a mismatch. Seattle looks like a 10 or 11 win team, and the Rams might struggle to get to six wins.

At home, giving up just 5.5 points, a bet on Geno Smith and the high-powered offense of Seattle seems like an obvious bet.

NFL Betting | Bet Rams vs. Seahawks
MyBookie Betting Lines for the Game

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MyBookie Odds for the Games

 

 

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Once the NFL schedule was set, everyone was anxious for Week 1! Although we still have a couple of months to wait, the betting public has already been putting money down for their Week 1 bets. We’ll have some interesting games in the opening week of the 2021-22 NFL season. Let’s take a look at some games where we think you can turn a little bit of cash into a lot of money. With that in mind, let’s jump right into action so you can plan your bets against their NFL odds.

2021 NFL Regular Season – Week 1 Matches To Wager On & Cash In

Jacksonville Jaguars (-2.5) @ Houston Texans

Bettors normally don’t like to put money down on a rookie quarterback starting in Week 1, but this could be a rare case. We’re not really sure what to make of Jacksonville quite yet. With a rookie NFL head coach in Urban Meyer, along with a Trevor Lawrence starting under center, there could be a lot of unknowns. Many are expecting Jacksonville to be much more competitive this season, as they had a very good draft, and made some very good free-agent signings.

The one thing we do know is that the Houston Texans are going to be very bad. It’s doubtful that Deshaun Watson will play for the Texans in this game. Even with Watson, the Texans weren’t going to be very strong, but without him, it’ll be a big struggle.

This game started out with Jacksonville being favored by 1.5 points, but quickly jumped to 2.5. Even with the quick jump, we like the Jaguars to win this one by double digits. It’s not so much that Jacksonville is going to be real good, it’s the fact that Houston is going to be really bad.

San Francisco 49ers (-7.5) @ Detroit Lions

We know that the 49ers should be contending for a playoff spot in the NFC. With numerous key players coming back from injury, the Niners should be one of the top teams in the NFC. The main question surrounding this squad will be who will be the starting quarterback in Week 1? Will we see Jimmy Garoppolo, or will rookie first rounder Trey Lance get the nod? Regardless, the Niners are substantially better than the Lions. Detroit is in rebuild mode, and every game will be a struggle for them.

This line could jump even higher, so if you feel confident in taking the Niners, you better do it now before the spread jumps even more.

Chicago Bears @ Los Angeles Rams (-7)

Los Angeles made the biggest move of the offseason when they acquired quarterback Matthew Stafford from the Detroit Lions. Stafford could be the piece that the Rams have been missing. The Rams have one of the top defenses in the league, and they have some very good skill position players. Having Stafford to run Sean McVay’s offense will be huge for the Rams.

The Chicago Bears lost some key players in the offseason. Losing cornerback Kyle Fuller could prove to be very costly. Offensively, the Bears will probably have Andy Dalton under center in Week 1. Even though they drafted Justin Fields in the first round, Matt Nagy has stated that Dalton is the starter.

The Bears are an aging team, and they just aren’t good enough to keep up with the Rams in this one. Take the Rams here.

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MyBookie Betting Lines for the Game

 

 

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Teams in the National Football League will soon head to training camps in preparation of another NFL Season. So far, information is limited on which teams have what it takes to win next year’s Super Bowl. One thing is for sure, though, from Week 1 to Week 18, NFL handicappers should find plenty of teams offering betting value. Keep reading for the three games in NFL Week 1 providing the most value. We analyze each game and hand out a pre-training camp pick so you can get ready to bet against their NFL odds.

NFL Week 1 Top 3 Games With Most Betting Value

2021 NFL Season

When: Sep. 9, 2021 – Jan. 9, 2022

Dallas Cowboys +6 ½ Vs Tampa Bay Buccaneers

When: Thursday, Sep. 9

The Buccaneers start defense of their Super Bowl victory against a team that didn’t even make the playoffs. But we shouldn’t discount the Dallas Cowboys chances to not only cover this enormous spread, but to also upset Tampa straight up.

For starters, Tampa’s offense may require a week or so to get on track. Tom Brady, Mike Evans, and Leonard Fournette return. But the Bucs weren’t super sharp early in the year last season.

Also, Dallas used their first six draft picks, all within the first four rounds, on defense. There’s no way the Cowboys’ D is as bad in 2021 as it was in 2020.

Cowboys’ quarterback Dak Prescott should be one-hundred percent. Dak has a ton of talent surrounding him. Dallas should play great and deserve the nod to win against the spread. If you’re not risk averse, consider backing the Boys on the moneyline.

NFL Pick: Dallas Cowboys

Jacksonville Jaguars Vs Houston Texans +3

When: Sunday, Sep. 12

Neither Houston nor Jacksonville should field a winning squad. It makes no sense, though, why Jacksonville is a -3 chalk on the road against the Texans. Houston will bad. Jacksonville could be worse.

Oddsmakers have read too much into the Jaguars’ changes. Sure, Urban Meyer was a great college coach. When was the last time a college coach had big time success in the NFL?

Yes, Jaguars’ quarterback Trevor Lawrence could be the next Peyton Manning. Peyton won 3 games his rookie season.

Again, Houston will be a terrible team. But as long as Deshaun Watson or Tyrod Taylor plays quarterback, the Texans should be better than the Jacksonville Jaguars. Not only that, but the Texans are loaded with veteran players and head coach David Culley has 27 years of NFL experience.

NFL Pick: Houston Texans

Cleveland Browns +6 Vs Kansas City Chiefs

When: Sunday, Sep. 12

Kansas City offers a touchdown on the spread due to reputation, not because of anything they did during the offseason. KC rebuilt their entire offensive line, which could yield benefits. Or it could be a disaster.

Starting left tackle Orlando Brown Jr. played right tackle with the Baltimore Ravens. There’s no telling if Brown Jr. will have as much success on the right side. Even if Brown develops into a lockdown LT, how much more will the O-line add to KC’s already explosive offense?

The Chiefs’ defense didn’t seem to improve that much. In regards to this game, the Browns field the best offensive line in the league, has a quarterback in Baker Mayfield who could take the next step, and should field an improved defense.

There’s a chance Cleveland controls the clock, which means the Browns should have a shot to win this in the fourth quarter. Consider backing the Browns on the moneyline as well as against the spread.

NFL Pick: Cleveland Browns

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MyBookie Betting Lines for the Game

 

 

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Already, odds are out for NFL Week 2. That’s how excited everyone has become about the upcoming NFL Regular Season. But before jumping to Week 2, we must contend with Week 1. Below are eight games football handicappers should wager as soon as possible, along with their NFL odds.

NFL Betting Preview for Games in Week 1

NFL 2020 Season Week 1

When: Thursday, Sep 10 – Monday, Sep 14

Thursday, Sep 10

Houston Texans / Kansas City Chiefs -10

The Chiefs opened as -6 ½ favorites. Already, the odds have flown to -10. Why? Without preseason games, teams like Kansas City, that are solid across the board and didn’t go through a ton of offseason changes, should flourish early in the season. Not only that but the Chiefs are the defending champs and Deshaun Watson can’t throw to DeAndre Hopkins. Soon, we could be staring at KC -12 or even -12 ½.

NFL Free Pick: Chiefs -10

Sunday, Sep 13

Las Vegas Raiders -1 ½ / Carolina Panthers

The Panthers look like a mess. Don’t get us wrong. New quarterback Teddy Bridgewater can ball. But, the Raiders had a bad season primarily because they were an orphan in Oakland. In Vegas, the Raiders’ talent should show. Don’t wait to back the Raiders. The odds should drift to Sin City by -3 or more.

NFL Free Pick: Raiders -1 ½

Philadelphia Eagles -6 / Washington Football Team

Washington has way more issues than their nickname. The Washington Maroons, which sounds like a good name for now, doesn’t have a veteran quarterback and the defense feels like a mess. Philadelphia believes they can win the Super Bowl. This line drifts past 7.

NFL Free Pick: Eagles -6

Indianapolis Colts -6 ½ / Jacksonville Jaguars

Lay anything less than 7 ½ on the Colts. The defense projects as a Top 5 unit, Tom Coughlin destroyed the Jags’ franchise, and new Indianapolis quarterback Philip Rivers should light up Jacksonville’s secondary.

NFL Free Pick: Colts -6 ½

L.A. Chargers -3 / Cincinnati Bengals

Oddsmakers and Bengal backers are putting too much stock into Joe Burrow. The LSU quarterback is talented, but rookie quarterbacks have trouble playing in the NFL after preseason games and a full offseason with their pro squad. Burrow is being thrown to the fire because the Bolts have a good defense. Tyrod Taylor, LAC’s QB, can run and doesn’t throw interceptions. Chargers end up as -5 ½ favorites. So, lay it as soon as possible.

NFL Free Pick: Chargers -3

Dallas Cowboys -2 ½ / L.A. Rams

The Rams don’t have much. The defense is decent. But, the offensive line remains a mess. The Cowboys look solid across the board. No way new head coach Mike McCarthy doesn’t get the most possible from Dak Prescott, Amari Cooper, and Zeke. This line should blow up to at least -3 ½ on the Boys.

NFL Free Pick: Cowboys -2 ½

Monday, Sep 14

Pittsburgh Steelers -3 ½ / New York Giants

Nate Solder, a key offensive line player for the New York Giants, has opted out. It means first pick Andrew Thomas must play right away. The Steelers’ defense should dominate the Giants’. Also, Big Ben Roethlisberger is back under center. It’s difficult to understand why Steel Town isn’t a -5 to -6 favorite today.

NFL Free Pick: Steelers -3 ½

Denver should be improved but . . . really? 2019 AFC Championship participant Tennessee gets 1 ½ points? Broncos won’t be improved enough to keep a Super Bowl contender from blasting them out of their own stadium.

NFL Free Pick: Titans +1 1/2

 

 

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NFL Week 1 kicks off on Thursday, Sep. 10 when the defending Super Bowl Champion Kansas City Chiefs battle the Houston Texans. In addition to wagering against the spread, we can make NFL moneyline bets. Check out this week’s top straight up NFL odds & free picks!

2020 NFL Odds | Week 1 Straight Up Picks

Sunday, Sep. 13 Matches To Bet On

Las Vegas Raiders -175 / Carolina Panthers +155

The Carolina Panthers are a solid team. But they may find it tough to beat the Raiders, who appear ready to become one of the better squads in the AFC this season. Carolina won’t suffer at the quarterback position. They will suffer on the defense where Luke Kuechley called it quits during the offseason. Back the Raiders.

NFL Pick: Las Vegas Raiders

Seattle Seahawks -130 / Atlanta Falcons +110

The ATL is one of the teams that will allow fans in their stadium. That could be just enough for the Falcons to eke out a victory. Atlanta is a good team on paper. Things haven’t turned out well for the Falcons since the Super Bowl run. No problem. Adding Todd Gurley to a squad that includes Julio Jones and Calvin Ridley makes the ATL a tough team at home.

NFL Pick: Atlanta Falcons

Arizona Cardinals +255 / San Francisco 49ers -310

By the time the Arizona Cardinals hit the field against the 49ers on Sunday, DeAndre Hopkins should be the highest paid wide receiver in the league. Hopkins will definitely help Kyler Murray take the next step. San Francisco should win, but AZ’s undervalued on the moneyline.

NFL Pick: Arizona Cardinals

Tampa Bay Buccaneers +155 / New Orleans Saints -175

In the Superdome, the Saints are always tough. But, here’s the thing. New Orleans has struggled with the Tampa Bay Buccaneers. For some reason, Tampa versus New Orleans is never an automatic win for either squad. So, now that Tampa has the GOAT under center, don’t they deserve a look to upset N’Awlins straight up in the first Brees versus Brady battle?

NFL Pick: Tampa Bay Buccaneers

Dallas Cowboys -160 / Los Angeles Rams +140

Backing the Rams at above even money is tempting. But the Cowboys’ offense is good enough to contain Aaron Donald and Jalen Ramsey. More importantly? The Rams’ offensive line must prove it can stand up to the Cowboys’ front seven.

NFL Pick: Dallas Cowboys

Green Bay Packers +120 / Minnesota Vikings -140

Aaron Rodgers could surprise everyone and play like the hall of fame quarterback he is. The Packers yielded 120.1 rushing yards per game last season, though. Instead of picking a linebacker or defensive lineman in the first round, they went with a backup quarterback. Good luck stopping the Vikings’ running game on Sep. 13.

NFL Pick: Minnesota Vikings

Monday, Sep. 14 Match To Bet On

Pittsburgh Steelers -245 / New York Giants +205

Pittsburgh is a better team with Big Ben Roethlisberger at quarterback than they are without him. Anybody who watched the Steelers last season know this. But Big Ben hasn’t played for almost an entire year. The Giants should be one of the most improved teams in the NFL this season. It make sense to back the home team on the undervalued moneyline.

NFL Pick: New York Giants

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MyBookie Betting Lines for the Game

 

 

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Get ready to strap on the helmets and the pads, as NFL Week 1 of the season is almost upon us. Players will be reporting to training camps all across the country later this month, with the start of the season now just about a month and a half away. We will have some preseason action to entertain us while we wait, but we all know that Week 1 of the season is when the real action kicks off.

The opening week of the 2018 NFL season has some rather tasty looking treats on offer, and we have chosen what we believe are the best games on the schedule. These are the match-ups that will make you want to get online and get in on the NFL betting action, so let’s take a look at what’s coming.

NFL Week 1 Must Bet Games – 2018 Season

Atlanta Falcons vs Philadelphia Eagles

When: Thursday, September 6th
Where: Lincoln Financial Field
NFL Week 1 Odds: Philadelphia Eagles -4

The new NFL season will open, as always, with the defending Super Bowl champions raising the banner at home. The Philadelphia Eagles have not been given any favors in the opening week, though, as they will need to cut the celebrations and focus on the visiting Atlanta Falcons, a team likely to push the champs all the way in the race for the NFC crown this season.

The Eagles will certainly be hoping for more of a party than the Patriots got last season when they were pounded by the Kansas City Chiefs in Week 1. No time for a hangover here, as the Eagles will need to come out with guns blazing against a killer Falcons offense.

Houston Texans vs New England Patriots

When: Sunday, September 9th
Where: Gillette Stadium
NFL Week 1 Odds: New England Patriots -6.5

Much has been made about the alleged in-house issues in New England over the past few months, and there is talk that this season will mark the end of the Brady/Belichick era. If that is indeed to be the case, then who can we expect to see become the kings of the AFC.

The Houston Texans would like to believe that they are part of the conversation, especially since they appear to have landed their franchise QB in DeShaun Watson. The young man certainly looked the part before going down with an injury in his rookie year, and it is going to be interesting to see how he matches up with the GOAT.

Kansas City Chiefs vs LA Chargers

When: Sunday, September 9th
Where: StubHub Center
NFL Week 1 Odds: Los Angeles Chargers -3

What we have here are a pair of teams with a legitimate shot at being in the playoffs this season. The Chiefs are going to have a period of adjustment, as they will be going with an unproven QB in Patrick Mahomes after shipping out Alex Smith. They will have a tough start on the road to an LA Chargers team that just missed out on the postseason last year.

We won’t know the whole story on Mahomes after just one game, but we could get an idea on what kind of season it could be for the Chiefs when we see how this one plays out.

LA Rams vs Oakland Raiders

When: Monday, September 10th
Where: Oakland Coliseum
NFL Week 1 Odds: Los Angeles Rams -3

We have a double-header on the opening Monday night of the season, but it is the late game that is the one worth staying up for. The LA Rams had a breakthrough season in 2017, although their one and done in the playoffs made for a disappointing end.

The Raiders had a poor year after coming into 2017 as one of the favorites, and they will be looking to bounce back under new head coach Jon Gruden. I would argue that this one has the potential to be the game of the week.

Rest of the Schedule (Week 1)

 

 

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The National Football League will be here before you know it! It’s never too early to predict Week 1 of the league. There are some fantastic games on tap for the first week. Let’s take a look at the Week 1 NFL odds Predictions.

2016 NFL Season Week 1 Betting Predictions

Tampa Bay Buccaneers vs. Atlanta Falcons

A battle of NFC South teams in Atlanta. The Tampa Bay Buccaneers are under new leadership, and have a ton of pieces back from a team that started last season strong. The Atlanta Falcons have been an organization that has kind of went backwards and a little sideways the last couple of seasons. How good is Matt Ryan is now the question. Obviously, Julio Jones is needed for the Falcons in this one. Look for Tampa Bay to be a much better defensive team this season, and start by slowing down Jones and the Falcons offense. The bet for this game is the Tampa Bay Buccaneers +3 over the Atlanta Falcons.

Green Bay Packers vs. Jacksonville Jaguars

The Jacksonville Jaguars are going to be one of the toughest young teams in the National Football League. The Jaguars drafted two guys in the draft that will likely start on the defense. The offense has shown signs of improvement over the last several seasons. Look for the best season of his career from . While the Jaguars are going to have a tough time winning this game over the veteran crew Green Bay Packers; the Jaguars will cover this spread. Look for a very competitive Week 1 game, but in the end, the bet for this game has got to be the Jacksonville Jaguars +10 over the Green Bay Packers.

Buffalo Bills vs. Baltimore Ravens

Two teams with massive question marks get together in the opening week of the National Football League season. Rex Ryan in his second season as the head coach of the Buffalo Bills has his work cut out for him. The Patriots appear to be the favorite in the AFC East, and Miami seemingly has improved, and the Jets are still going to be a competitive team. For Baltimore, can they bounce back after a horrendous season of a year ago? Who is going to be the productive running back for the Ravens this season? This will be a heck of a game, but in the end, you have to side with the home team. Bet the Baltimore Ravens -3 over the Buffalo Bills in Week 1.

There you go! There is a trio of National Football League Week 1 Predictions. Keep your eyes on the league, and we will let you know if there is any change in betting line, or reason to make a change in prediction.