Signup

Week 3 of the NFL season is upon us—and every game counts more than ever.

Surprises, stats, and upsets are becoming the norm.

Which teams are peaking?

Which underdogs could cash in?

We’ve got two in-house MyBookie experts laying out their sharpest picks, best bets, and value plays for this pivotal week.

MyBookie Writer’s NFL Week 3 Picks You Can’t Miss

Whether you’re chasing coverages, chasing big payouts, or trying to squeeze every edge out of your parlay, this is your chance to see what real inside knowledge looks like.

I’ll warn you: these aren’t the generic picks you’ll find everywhere else.

These picks are forged from trend analysis, injury reports, line movement, and deep knowledge of matchups.

If you like winning, you’ll want to read every NFL line.

Why Sign In Before Making Your Picks

And if you haven’t logged in or claimed your MyBookie account yet, now’s a perfect time.

Some of these picks may only be accessible once you’re in.

Ready to sharpen your Week 3 betting strategy?

Let’s jump into the picks.

NFL Week 3 Expert Picks from D.S. Williamson & Henry Watkins

Below are the sharpest selections straight from our two in-house experts. No fluff, no filler—just their Week 3 NFL betting picks ready for action.

Henry Watkins | MyBookie Sports Writer

Week 3 Straight Up Picks

I am going to take a bit of a risk here, particularly if you are putting together a parlay ticket.

I am going with a pair of favorites and an underdog.

The Pittsburgh Steelers are 1-1, with mistakes costing them last week.

I like them to bounce back with a win on the road against the Patriots.

The Philadelphia Eagles are perfect to start the season, and while they have a tough one coming up against the Rams, I like them at home.

For the longshot pick, I am taking the Carolina Panthers at home over the Falcons.

It’s a risky one, but I am all in.

Henry Watkins Week 3 SU Picks in a Parlay

Pittsburgh @ New England – SU Parlay Pick: Steelers
Los Angeles @ Philadelphia SU Parlay Pick: Eagles
Atlanta @ Carolina SU Parlay Pick: Panthers
NFL Lines

Week 3 ATS Picks

Let’s start with the Thursday game and what looks like a mismatch.

The Bills look like the real deal, while the Dolphins look bad.

I’m on the Bills at -13.

Another team that has looked very good through the opening 2 weeks is the Green Bay Packers.

They are on the road in Cleveland this weekend and look at the Browns with good value to me at -8 ½.

Finally, we have the Sunday night game, with the Cowboys on the road against the Bears.

Dallas is -1, but I think they will have a much more comfortable win.

Henry Watkins Week 3 ATS Picks

Miami @ Buffalo – ATS Bet Bills at -13
Green Bay @ Cleveland ATS Bet Browns at -8 ½
Dallas @ Chicago ATS Bet Cowboys at -1
NFL ATS Lines

NFL Week 3 O/U Picks

The Indianapolis Colts have scored 63 points in 2 games and could well run up that number this weekend against the Tennessee Titans.

With that in mind, I like the OVER 43 ½.

Neither the Raiders or the Commanders are setting the world alight on offense, but I think we will see them both put up points this weekend, so I like the OVER 44 ½.

In terms of low scoring games, I think we might see the Saints and Seahawks keep it tight, so I am taking the UNDER 41 ½.

Henry Watkins Week 3 O/U Picks

Indianapolis @ Tennessee – Total Bet OVER 43 ½
Las Vegas @ Washington Total Bet OVER 44 ½
New Orleans @ Seattle Total Bet UNDER 41 ½
NFL O/U Lines

Henry’s Week 3 card in the MyBookie Writer’s NFL Week 3 Picks delivers a balance of safe favorites and bold underdog shots, giving bettors both stability and upside—perfect for building parlays or spotting value on spreads and totals.

D.S. Williamson | MyBookie Sports Writer

Soon to come.

Final Throughts on Betting NFL Week 3

There you have it — two expert-driven pick sheets for NFL Week 3, built for bettors who demand more than just guesswork.

Now it’s your move: lock in your favorites, stack up that parlay, or ride the underdog.

Logged-in users will see exclusive edges, special NFL odds, and value you won’t find elsewhere.

Ready to turn insight into profit?

MyBookie Writers’ NFL Week 3 Picks

From spreads to totals and moneylines, our in-house writers break down where the real betting value lies for NFL Week 3.

Skip the noise—these aren’t casual guesses. They’re sharp insights designed to help you lock in smarter bets and bigger payouts.

BLITZ THE REELS TO WIN A PIECE OF $70K!

1. Play games in the Sack the Slots section (min bet: $1)
2. The more you wager, the higher your score will be
3. Climb the leaderboard to win a piece of $14K each week!

⤵️ ⤵️https://t.co/esG9qmL7aZ pic.twitter.com/A1wsi2U40A
— MyBookie – Bet With The Best (@MyBookie) September 15, 2025

^ Top

2025 NFL Season Betting Guide

What are you waiting for… Start learning today with MyBookie Betting!

I have read enough, I need to place my bet now. What to do?

MyBookie Online NFL Lines
MyBookie Odds for the Games

Elevate your NFL Season with MyBookie + Loyalty Rewards Program

Start to earn points with the Sportsbook and Casino Loyalty Program to level up, get exclusive bonuses and rakeback in every stage of the 2025/26 Season: Draft, Offseason, Preseason, Regular Season, Playoffs and Super Bowl.

Join the MyBookie program, subscribing will guarantee your share of $15,000 in free plays.

Bet On NFL top betting odds, anywhere, anytime

About the Author

D.S. Williamson
Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.