NFL Week 4 kicks off on Thursday, Sep. 30, when the Cincinnati Bengals host the Jacksonville Jaguars a -7 ½ favorite. Top Sunday matchups include undefeated Carolina at Dallas, the 3-0 Denver Broncos hosting the Baltimore Ravens, and Tom Brady leading the Buccaneers in his return to New England. Check out NFL odds, analysis, and free picks for every game in NFL Week 4.
2021 NFL Regular Season – Week 4 Odds Analysis & Picks
2021 NFL Week 4
- When: Thursday, Sep. 30 – Monday, Oct. 4
Jacksonville Jaguars vs Cincinnati Bengals -7 ½
- When: Thursday, Sep. 30
Cincinnati’s 24-10 win over Pittsburgh impressed. But the Bengals offer a lot of points in this game. Jacksonville is a bad football team. Still, the Jags can score, they put up 19 in a loss to AZ. Taking the points makes sense.
NFL Week 4 Pick: Jacksonville Jaguars
Washington Football Team -1 ½ vs Atlanta Falcons
- When: Sunday, Oct. 3
Atlanta welcomes the Commanders a week after upsetting the Giants on the road. The ATL has played well in 2-of-3 games. Washington’s defense is an absolute mess. Backing Matt Ryan and the Falcons on the moneyline is the way to go.
NFL Week 4 Pick: Atlanta Falcons
Detroit Lions vs Chicago Bears -3
- When: Sunday, Oct. 3
If not for Ravens’ kicker Justin Tucker breaking the field goal record with his amazing 66 yarder, Detroit would have won their first game of the season. Bears’ coach Matt Nagy hasn’t said who he will start at quarterback. Right now, even though they haven’t won a game yet, the Lions might be the better team.
NFL Week 4 Pick: Detroit Lions
Tennessee Titans -7 ½ vs New York Jets
- When: Sunday, Oct. 3
Wow the Jets are bad. A new coach, a new quarterback, and even a new attitude hasn’t changed the fact that the New York Jets are an awful team. But with that being written, the Titans have now covered in two straight, which feels like their limit.
NFL Week 4 Pick: New York Jets
Cleveland Browns -2 vs Minnesota Vikings
- When: Sunday, Oct. 3
So the Browns may be the better team, but Minnesota showed something versus Seattle in their last. At home, the Vikings rule. Minnesota’s offense will score in this game. There’s a good chance Kirk Cousins outplays Baker Mayfield. The Vikings are the moneyline pick.
NFL Week 4 Pick: Minnesota Vikings
Indianapolis Colts vs Miami Dolphins -1 ½
- When: Sunday, Oct. 3
Both squads could be missing their starting quarterbacks. Neither team has played great this season. This could go either way. We’ll side with the Dolphins because their defense should be slightly better.
NFL Week 4 Pick: Miami Dolphins
Carolina Panthers vs Dallas Cowboys -4 ½
- When: Sunday, Oct. 3
The Panthers traded for cornerback CJ Henderson after top pick Jaycee Horn broke his foot in the win over the Texans. Henderson is a good corner. But he faces Dallas’ top offense. More importantly, Dallas’ D is playing lights out. The Boys win and cover.
NFL Week 4 Pick: Dallas Cowboys
New York Giants vs New Orleans Saints -7 ½
- When: Sunday, Oct. 3
For NYG, this is a bad matchup. The Saints boast one of the best defenses in the league. Not only that, but New Orleans’ QB Jameis Winston is a different player. He takes what the defense gives him and then waits for long opportunities. Saints should dominate.
NFL Week 4 Pick: New Orleans Saints
Houston Texans vs Buffalo Bills -16 ½
- When: Sunday, Oct. 3
16 ½ is a ton of points. Should Buffalo cover? Yes. But we’re hesitant to land on the Bills because Houston quarterback Davis Mills played well agianst Carolina’s terrific defense. Texans can keep this closer than the spread.
NFL Week 4 Pick: Houston Texans
Kansas City Chiefs -6½ vs Philadelphia Eagles
- When: Sunday, Oct. 3
Everyone’s all over the Chiefs. We’re not. The Chiefs can’t stop the rush. So if Eagles LT Jordan Mailata plays, he’s listed as questionable, Philly will keep this within the number.
NFL Week 4 Pick: Philadelphia Eagles
Arizona Cardinals vs Los Angeles Rams -6
- When: Sunday, Oct. 3
Matthew Stafford can break down any defense, including the Cardinals’. Arizona has a good offense, but this is a road game versus the best team in the division. Rams to cover is the play.
NFL Week 4 Pick: Los Angeles Rams
Seattle Seahawks vs San Francisco 49ers -2 ½
- When: Sunday, Oct. 3
Seattle went up 14-0 over the Minnesota Vikings. They ended up losing 30-17. The Hawks rank 32nd in yards allowed per. Opponents average 440.3 yards each game versus Seattle. San Francisco should easily cover this spread.
NFL Week 4 Pick: San Francisco 49ers
Baltimore Ravens vs Denver Broncos -1
- When: Sunday, Oct. 3
On paper, it looks like Denver should have no issue covering this spread. But Denver is 3-0 after beating the Giants, Jaguars, and Jets. We don’t know how good the Broncos’ defense really is. Jackson and the Ravens will challenge Denver’s D for sure. Baltimore is the pick.
NFL Week 4 Pick: Baltimore Ravens
Pittsburgh Steelers vs Green Bay Packers -6 ½
- When: Sunday, Oct. 3
Although Pittsburgh lost to the Bengals, T.J. Ward didn’t play. As of Tuesday, Sep. 28, Ward is listed as questionable. If Ward plays, Pittsburgh can cover. If he doesn’t, the Packers should cover. We’re leaning towards Ward playing.
NFL Week 4 Pick: Pittsburgh Steelers
Tampa Bay Buccaneers -6 vs New England Patriots
- When: Sunday, Oct. 3
The Buccaneers should cover this spread. However, the Patriots have a good defense while Tampa has no rushing attack. Bill Belichick will come up with a great defensive game plan to mellow out Tom Brady and the Buccaneers’ offense. Taking the points makes sense.
NFL Week 4 Pick: New England Patriots
Las Vegas Raiders vs Los Angeles Chargers -3
- When: Monday, Oct. 4
This will be a much closer game than many expect. Don’t let the Chargers victory over the Chiefs fool you. Kansas City has no rushing attack. The Raiders can run the football. Not only that, but their defense is playing great and this is a rivalry contest.
NFL Week 4 Pick: Las Vegas Raiders
NFL Betting News
Odds and Lines: NFL odds | Super Bowl | Playoffs | AFC | NFC
- NFL Latest Line: A Look at Each Team’s Projected Success in 2024
- Kansas City Chiefs Odds to Win: Examining the Upcoming Season!
- Betting the NFL Season: Can We Identify Teams Likely to Start 0-5?
- Unlocking the 49ers’ Potential: NFL Odds for the Season plus Expert Analysis
- Bet On NFL Draft and the Top Quarterback Picks for 2024/25 Season
