NFL Week 5 Picks & Predictions – MyBookie Writers’ Best Bets

San Francisco 49ers at LA Rams -5.5

The San Francisco 49ers head to SoFi to take on a Rams team that sits at 3-1 and is a blocked field goal away from being 4-0.

The Rams are legit, a real Super Bowl contender, and has be the play in this.

The line has moved up 2 points since opening at -3.5.

So the money is flowing to Matthew Stafford and Puca Nacua, the best QB/WR combo in the league.

San Francisco’s defense struggled to keep Trevor Lawrence and the Jags from pasting them with 26 points in a home loss.

There’s no way Staff and Puca don’t get it going in this.

Rams cover the -5.5.

Writer’s Week 5 Pick: Rams -5.5
NFL Betting Lines

New York Giants at New Orleans Saints -1.5

The Giants looked impressive when beating the LA Chargers in NFL Week 4.

But before declaring Jaxon Dart the next coming of Phil Simms, it’s important to note that the Bolts sacked Dart 5 times.

So if Justin Herbert hadn’t thrown 2 picks, who knows what would have happened?

Omarion Hampton rushed like a beast against the Giants’ D, rolling to 128 yards and a TD.

Alvin Kamara will rush behind a Saints line that’s almost one hudnred percent healthy.

Spencer Rattler has a 5-to-1 TD to INT ratio and is completing close to 67% of his passes.

Saints get their first win of the season via a cover victory.

Writer’s Week 5 Pick: Saints -1.5
NFL Betting Lines

Minnesota Vikings -3.5 at Cleveland Browns

Minnesota should win this game but that doesn’t mean they cover.

The Browns have been fantastic at home, losing by a point to the Bengals in a 17-16 Week 1 game and beating the Packers by 3 in a 13-10 game.

Cleveland still boasts one of the best rush defenses in the league.

So the Vikings should struggle with Carson Wentz under center.

If you’re bold, back the Browns on the moneyline.

Writer’s Week 5 Pick: Browns +3.5
NFL Betting Lines

D.S. Williamson’s Week 5 card in the MyBookie Writers’ NFL Week 5 Picks leans on sharp line reads and matchup edges, pairing proven favorites with value underdogs to uncover the best angles for parlays, spreads, and totals this week.

---

About the Author

• D.S. Williamson
• Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.

NFL Week 5 SU Picks

While the 49ers and Rams are both sitting at 3-1 over the first 4 weeks, I have much more faith in the Rams, which is why I am on them to win.

The panic button has not yet been pressed in Baltimore, but at 1-3, the Ravens need a win, which I think they get against the Houston Texans.

The LA Chargers saw their perfect start come to an end last weekend, and they have another tough one against the Commanders.

I think they bounce back with the win.

NFL Week 5 SU Picks

49ers @ Rams – SU Pick: Rams
Texans @ Ravens – SU Pick: Ravens
Commanders @ Chargers – SU Pick: Chargers
Bet NFL Week 5 Odds

NFL Week 5 ATS Picks

The Indianapolis Colts took their first loss last weekend, but I like them to win and cover against the Raiders at -7.

The Philadelphia Eagles are one of only 2 unbeaten teams in the league, and I like them to make it 5 in a row over Denver, covering the 3 ½ point spread.

The Bills are the other unbeaten team, and they have looked outstanding to this point.

I think they blow out the Patriots, easily covering the 7 ½ point spread.

NFL Week 5 ATS Picks

Raiders @ Colts – ATS Pick: Colts -7
Eagles @ Broncos – ATS Pick: Eagles -3½
Patriots @ Bills – ATS Pick: Bills -7½
NFL Week 5 Point Spreads

NFL Week 5 O/U Picks

The Dolphins offense has been decent, but that has not translated to wins.

They have a shot to make it 2 in a row over the Panthers, and I like the OVER 44 ½.

The Titans are winless, and their D has more holes than Swiss cheese.

Look for Arizona to run up the score and get OVER the 41 ½ point total.

The Chiefs offense finally looked like it should last weekend, but I think we get a tight battle against the Jaguars this weekend, so I am on the UNDER 46 ½.

NFL Week 5 O/U Picks

Panthers @ Dolphins – Total Pick: OVER 44½
Cardinals @ Titans – Total Pick: OVER 41½
Jaguars @ Chiefs – Total Pick: UNDER 46½
NFL Week 5 Totals

Henry’s Week 5 card in the MyBookie Writers’ NFL Week 5 Picks mixes steady favorites with sharp underdog shots, delivering both safe value and high-upside plays—perfect for parlays, point spreads, and totals this week.

---

About the Author

• Henry Watkins
• Henry is originally from Scotland but now resides in Metro Atlanta with his chef wife Penny. As well as working as a Sports freelance writer, he also writes horror fiction. Watson is the author of Karaoke Night, Crueller, and Off The Grid.

FIRST TD $10K JACKPOT

The show goes on! Bet the first touchdown for the Seahawks vs Cardinals game and have a chance at securing a piece of the $10K jackpot!

2 customers won $5K last week!

➡️ https://t.co/qkAYhnp4nm

#BetWithTheBest pic.twitter.com/3KJ6lNVd6f

— MyBookie – Bet With The Best (@MyBookie) September 24, 2025

Welcome Bonuses from MyBookie : DOUBLE YOUR FIRST CRYPTO DEPOSIT!