NFL Week 4 Writers’ Picks & Best Bets 2025

NFL Week 4 is here, and our writers are back with their best bets and predictions for every matchup.

From against the spread (ATS) picks to over/under calls and even a few potential upset alerts, we’ve got you covered with analysis you won’t find anywhere else.

Whether you’re looking for NFL Week 4 betting picks to build your parlay, or just want to see which teams our experts trust on the moneyline, this guide delivers the sharp insights you need.

Plus, don’t miss our take on the special Steelers vs Vikings Dublin game, one of the most unique spots on the 2025 NFL schedule.

MyBookie Writer’s NFL Week 4 Picks & Predictions

From ATS locks to over/under gems and sneaky upset alerts, our writers break down the best betting angles for Week 4 of the 2025 NFL season.

Forget the cookie-cutter advice you’ll find everywhere else—these are real expert picks built on betting trends, injury updates, and sharp line movement analysis.

Every parlay starts with the right call.

Our NFL Week 4 betting picks give you the insight to hit spreads, totals, and moneylines with confidence.

If you want an edge this week, you’ll want to follow every one of our writers’ best bets.

Why Sign In Before Checking Week 4 Picks

If you haven’t logged in or activated your MyBookie account yet, now’s the perfect time.

Some of the sharpest NFL Week 4 betting picks from our writers are best enjoyed once you’re in.

Looking to sharpen your Week 4 betting strategy and parlay plays?

NFL Week 4 Expert Picks from D.S. Williamson & Henry Watkins

Here are the sharpest calls from our two in-house experts—no fluff, no filler.

Just straight NFL Week 4 betting picks ready for action.

Henry Watkins | MyBookie Sports Writer

NFL Week 4 SU Picks

International games always feel like a bit of a crapshoot, but I am going with the Steelers to adjust better than the Vikings, especially after a gritty win last week.

Pittsburgh is the underdog here, but I still like them.

The Atlanta Falcons already look like they have an issue at QB, which does not bode well for their season overall.

Taking the Washington Commanders to beat Atlanta feels like the easiest pick of the week.

I almost took the Colts and Rams for one of my O/U picks, but I am rolling with the Colts to win as the underdog in this one.

Week 4 SU Picks

Pittsburgh vs Minnesota (Dublin) – SU Pick: Steelers
Atlanta @ Washington – SU Pick: Commanders
Indianapolis @ LA Rams – SU Pick: Colts
Bet NFL Week 4 Odds

NFL Week 4 ATS Picks

I had the Carolina Panthers for the upset win last week and cashed that ticket, and I am taking them again, this time to cover at +5 ½ versus the Patriots.

The Chicago Bears are coming off a huge win against the Cowboys las weekend and have what looks like another winnable game against the Raiders this week.

They are slight underdogs at +1 ½, so I am taking them to cover.

If the Miami Dolphins are to get their season going, they are probably going to do it against the Jets, so I am taking them at -2 ½.

Week 4 ATS Picks

Carolina @ New England – ATS Pick: Panthers +5½
Chicago @ Las Vegas – ATS Pick: Bears +1½
Miami @ NY Jets – ATS Pick: Dolphins -2½
Bet NFL Point Spreads

NFL Week 4 O/U Picks

The Detroit Lions are coming off a huge win over the Ravens, where they racked up 38 points.

More of the same this week against the Browns, so I am taking the OVER 44 ½.

The Titans and the Texans are both struggling to win and to put points on the board, yet I still feel that the 38 ½ point total is a little on the low side, hence the OVER.

I am a little concerned about the Bengals QB situation, but I still like the OVER 44 points in their Monday night game against Denver.

Week 4 O/U Picks

Cleveland @ Detroit – O/U Pick: OVER 44½
Tennessee @ Houston – O/U Pick: OVER 38½
Cincinnati @ Denver (MNF) – O/U Pick: OVER 44
Bet NFL Totals

Henry’s Week 4 card in the MyBookie Writer’s NFL Week 4 Picks blends reliable favorites with bold underdog calls, giving bettors both steady value and high-upside plays—ideal for parlays, spreads, and totals this week.

About the Author

Henry Watkins
Henry is originally from Scotland but now resides in Metro Atlanta with his chef wife Penny. As well as working as a Sports freelance writer, he also writes horror fiction. Watson is the author of Karaoke Night, Crueller, and Off The Grid.

D.S. Williamson | MyBookie Sports Writer

Minnesota Vikings -2.5 at Pittsburgh Steelers

The Steelers’ D finally got it together in NFL Week 3, holding the Pats to 14 points in a 21-14 win.

Carson Wentz and Jordan Mason went nuts for the Vikings, which is why Minnesota is a -2.5 chalk.

But let’s get real.

Pittsburgh has enough on offense, and the defense has gelled, which means the Steelers are an overlay at +2.5.

NFL Week 4 Pick: Steelers +2.5

NFL Betting Lines

New Orleans Saints at Buffalo Bills -16.5

The Bills for sure can cover this line.

One thing to note is that the spread went from Buffalo -13.5 to -16.5.

Before jumping on the Bills, though, it’s clear that Buffalo will rush out to a big lead and then coast.

So 16.5 points becomes a lot.

Too many, in fact, because a Saints backdoor cover is possible if Buffalo’s starters exit the game in the fourth quarter.

The Saints will play hard.

NFL Week 4 Pick: Saints +16.5

NFL Betting Lines

LA Chargers -6.5 at New York Giants

This is a no-brainer pick.

Sure, the Giants have shown flashes of being a mediocre team instead of a disaster.

But those flashes came against the mess that is the Dallas Cowboys.

Also, once KC got it going, that game was never in doubt.

The Bolts might be the best team in the AFC.

Chargers should cover the line no problem.

Pick: Chargers -6.5

NFL Betting Lines

Green Bay Packers -6.5 at Dallas Cowboys

The Sunday Night Football game should be a good one but it won’t.

Micah Parsons returns to Big D and he and the Pack will be fired up to take it to a Dallas offense without CeeDee Lamb.

Also, Jordan Love gets a chance to destroy the worst secondary in football, at least based on stats.

And the Pack lost to the Browns in NFL Week 3.

So motivation is there. GB covers.

NFL Week 4 Pick: Packers -6.5

NFL Betting Lines

About the Author

D.S. Williamson
Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.

Final Thoughts: NFL Week 4 Writers’ Picks

Our writers are split between bold underdog calls and reliable favorites this week.

From the Steelers at +2.5 in the international matchup, to the Saints sneaking inside the big Buffalo spread, and chalk like the Chargers -6.5 and Packers -6.5, there’s plenty of value across the board.

These betting picks for NFL Week 4 are balance of smart line that come with matchup insights that offer multiple ways to attack the slate—whether you’re building a parlay, targeting spreads, or playing totals.

Don’t just watch the games—bet smarter with MyBookie’s NFL Week 4 odds and follow our experts all season long.

Ready to turn insight into profit?

MyBookie Writers’ NFL Week 4 Picks

From point spreads to over/under totals and moneyline calls, our in-house writers highlight where the real betting value is for NFL Week 4.

Forget the noise—these aren’t casual guesses.

They’re sharp insights built to help you make smarter bets and chase bigger payouts this week.

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