NFL Week 12 Picks & Predictions from MyBookie Writers

Since 2008, D.S. Williamson has written about sports and sports handicapping.

His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to sportsbook odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.

Indianapolis Colts at Kansas City Chiefs -3.5

Kansas City hosting Indianapolis is this week’s top matchup — and it comes with real upset potential.

The Kansas City Chiefs are in desperate need of a win, but the Indianapolis Colts had a full week to prep and match up surprisingly well.

Yes, the Chiefs are dangerous in “must-win” spots… but Indianapolis is catching value on both the spread and moneyline. Their defense matches up well enough to keep this close late.

Writer’s Week Pick: Colts +3.5 & Small ML Play (Value Side)

Colts vs Chiefs Betting Lines

Atlanta Falcons -2.5 at New Orleans Saints

Atlanta is in chaos — and New Orleans is the sharper, more stable side coming off the bye.

The Atlanta Falcons will rely on Kirk Cousins the rest of the season, and his first outing was a disaster. Even if Michael Penix Jr. were available, the Falcons’ direction is shaky.

The New Orleans Saints discovered real momentum before the bye when rookie QB Tyler Shough threw for 282 yards, 2 TDs, and completed over 70% of his passes. With extra prep time and home-field energy, New Orleans is live for an outright win.

Writer’s Week Pick: Saints Moneyline (Better Team Right Now)

Falcons vs Saints Betting Lines

Tampa Bay Buccaneers at Los Angeles Rams -6.5

The Rams are red-hot and playing like a legitimate Super Bowl contender.

The Tampa Bay Buccaneers are solid — Baker Mayfield is having a strong season and the defense remains respectable. But the Los Angeles Rams are on another level right now.

At SoFi Stadium, LA’s offense and pass rush should separate late. Tampa can compete early, but the Rams’ firepower and balance make the full-game cover the right side.

Writer’s Week Pick: Rams -6.5 (Super Bowl Form)

Buccaneers vs Rams Betting Lines

Jacksonville Jaguars -2.5 at Arizona Cardinals

Jacksonville smashed Los Angeles last week — but bettors shouldn’t overreact.

The Jacksonville Jaguars dominated the Chargers 35–6… but LA was forced to start Trevor Penning at LT, a failed Saints project who struggled throughout his time in New Orleans. The pass-rush mismatch made Jacksonville’s win look more impressive than it really was.

That won’t be the case against an Arizona Cardinals team that refuses to quit and nearly stormed back against San Francisco despite trailing by more than 20.

Writer’s Week Pick: Cardinals Moneyline (Live Home Dog)

Jaguars vs Cardinals Betting Lines

D.S. Williamson’s latest NFL picks lean heavily on value plays, situational edges, and fading misleading box scores. Track all NFL betting odds and jump on early movement before kickoff.

Henry is originally from Scotland but now resides in Metro Atlanta with his chef wife Penny.

As well as working as a Sports freelance writer, he also writes horror fiction.

Watson is the author of Karaoke Night, Crueller, and Off The Grid.

NFL Week 12 SU Picks

Why wait until Sunday when Thursday night offers the clearest play on the board? I’m backing Buffalo in primetime.

The Buffalo Bills are in a strong bounce-back spot and match up well with a New England Patriots team still searching for offensive rhythm.

One of the weekend’s best matchups features the Indianapolis Colts taking on the Kansas City Chiefs. It should be tight throughout, but KC at home gets the nod in a close SU decision.

For value, I’m rolling with the New England Patriots to beat the Cincinnati Bengals outright — a sharper play than some of the more obvious favorites on the board.

NFL Week 12 SU Picks

Bills vs Patriots – SU Pick: Bills
Colts vs Chiefs – SU Pick: Chiefs
Patriots vs Bengals – SU Pick: Patriots
Bet NFL Week 12 Odds

NFL Week 12 ATS Picks

This week’s ATS board features injury mismatches and bounce-back opportunities — perfect for targeting inflated or discounted spreads.

The Detroit Lions are coming off a tough loss, which spells trouble for a bruised-up New York Giants squad. Detroit should comfortably cover the -10 number at home.

The Baltimore Ravens haven’t looked dominant, but they draw a favorable matchup against the injury-riddled New York Jets. Laying 13½ isn’t ideal, but the Ravens should still clear it.

The Pittsburgh Steelers may be without Aaron Rodgers, but they’ve shown enough grit to keep things close — and even win — against the Chicago Bears. I like Pittsburgh +2½.

NFL Week 12 ATS Picks

Lions vs Giants – ATS Pick: Lions -10
Ravens vs Jets – ATS Pick: Ravens -13.5
Steelers vs Bears – ATS Pick: Steelers +2.5
Bet NFL Week 12 Lines

NFL Week 12 O/U Picks

Totals this week include two likely shootouts and one old-school defensive grind.

The rivalry matchup between the Philadelphia Eagles and the Dallas Cowboys sets up perfectly for offense — I’m on the OVER 49½.

The Los Angeles Rams and Tampa Bay Buccaneers have both been strong offensively, making this another spot where OVER 49½ feels like the right side.

Meanwhile, expect a slow-paced, defensive battle between the Cleveland Browns and Las Vegas Raiders. UNDER 37½ is the play.

NFL Week 12 O/U Picks

Eagles vs Cowboys – Pick: OVER 49.5
Rams vs Buccaneers – Pick: OVER 49.5
Browns vs Raiders – Pick: UNDER 37.5
Bet NFL Week 12 Totals

Henry Watkins’ Week 12 selections in the MyBookie Writers’ NFL Picks combine spread value, rivalry shootouts, and sharp SU angles. Stay locked in with the latest NFL betting odds and track line movement throughout the week.