NFL Week 5 Odds Overview & Predictions for Each Game

NFL Week 5 Odds Overview & Predictions for Each Game

Written by on October 5, 2021

We saw some great action in NFL Week 4, including the Seattle Seahawks beating the San Francisco 49ers. NFL Week 5 starts off with Seattle hosting the Los Angeles Rams, week 4 losers to the Arizona Cardinals. Other great matchups in week 5 include New Orleans at Washington, the Cowboys hosting the Giants, Browns versus Chargers, and the most important game so far in the AFC, Kansas City against Buffalo on NFL Sunday Night Football.  Check out a more in depth look at NFL odds for Week 5.   

2021 NFL Week 5 Betting Action

When: Thursday, Oct. 7 – Sunday, Oct. 10


Thursday, Oct. 7

Los Angeles Rams -2 / Seattle Seahawks

At first glance, it looks as if Seattle should be the chalk. After all, the Seahawks beat San Francisco on the road in week 4 while the Rams lost to the Cardinals. Ah, but SF quarterback Jimmy Garoppolo got hurt. Also, the Rams always bounce back from tough losses.

NFL Week 5 Pick:
Los Angeles Rams


Sunday, Oct. 10

New York Jets / Atlanta Falcons -3 ½

In at least one game this season, the Jets are going to win and cover. It just won’t be against the Atlanta Falcons on Sunday. Expect at least a 7 point ATL victory. 

NFL Week 5 Pick:
Atlanta Falcons


Miami Dolphins / Tampa Bay Buccaneers -10 ½

The defending champs will have their hands full with the tough Miami Dolphins. The Fins’ defense is a decent unit while Tampa could be down to Richard Sherman at one corner spot and a player to be named at a later date at the other. The Dolphins will keep this close.  

NFL Week 5 Pick:
Miami Dolphins


Philadelphia Eagles / Carolina Panthers -4

Jalen Hurts is doing all he can to keep Philadelphia competitive, but it will be difficult to score more than 10 against the Panthers. Then again, Philly should have the best quarterback on the field. That’s how bad Sam Darnold played against Dallas. Darnold panics. So we’re backing the Eagles against the spread.

NFL Week 5 Pick:
Philadelphia Eagles


New Orleans Saints -1 / Washington Football Team

Instead of going for the jugular, the Saints allowed the Giants to hang around until NYG tied the game and then upset New Orleans in overtime. Don’t expect Sean Payton to make the same mistake versus the WFT. Payton’s going to open the playbook versus the league’s 29th ranked defense in yards allowed per game.

NFL Week 5 Pick:
New Orleans Saints


Tennessee Titans / Jacksonville Jaguars +170

The Titans have a bad offense, which is why the Jaguars are this week’s top moneyline underdog play. Jacksonville plays hard. Not only that, but this is on the Jaguars’ turf.

NFL Week 5 Pick:
Jacksonville Jaguars moneyline


Detroit Lions / Minnesota Vikings -7 ½

In week 4, Detroit disappointed big time. The Lions allowed the Bears to score at will in the first half. Detroit tried to rally, but couldn’t get closer than 14 points. The Vikings should have played more aggressively against the Cleveland Browns. They didn’t and it cost them. Expect Minnesota’s offense to let loose on Sunday.

NFL Week 5 Pick: Minnesota Vikings


Denver Broncos / Pittsburgh Steelers -1

Denver quarterback Teddy Bridgewater might not play. Even if he doesn’t, the Broncos are the pick. Pittsburgh can’t score and the Steelers face one of the best defenses in the league. Drew Lock is good enough to lead the Broncos to at least 17 points, which is all they will require to win this game.

NFL Week 5 Pick:
Denver Broncos


Green Bay Packers -3 ½ / Cincinnati Bengals

Rodgers and the Pack are vulnerable to the moneyline upset. Green Bay almost gave up a lead agianst the Steelers in their last. The Bengals grabbed a victory over the Jaguars. Cincinnati has a good enough offense to stay within a field goal.

NFL Week 5 Pick:
Cincinnati Bengals


New England Patriots -9 / Houston Texans

Houston fields one of the worst NFL offenses in history while the Patriots were unlucky to lose their Sunday night battle versus the Tampa Bay Buccaneers. The Pats should roll to at least a 14 point victory.

NFL Week 5 Pick:
New England Patriots


Cleveland Browns / Los Angeles Chargers pk

Heading into their Monday night game versus the Raiders, the Chargers allow 170 rushing yards per game. Cleveland rushes for 177 per. We’re all over the Browns.

NFL Week 5 Pick:
Cleveland Browns


Chicago Bears / Las Vegas Raiders -4.5

Justin Fields played okay in a home win win against the Detroit Lions. He faces a much tougher task on Sunday versus the Raiders in Las Vegas. Las Vegas is a good football team. They should cover this spread.

NFL Week 5 Pick:
Las Vegas Raiders


New York Giants / Dallas Cowboys -7

Dak Prescott and the Cowboys’ offense will score at least 35 in this. Dallas’ defense has become a very good unit. The Giants head into Big D after upsetting the Saints in NFL Week 4 and could bounce. All of it adds up to a Dallas blowout victory.

NFL Week 5 Pick:
Dallas Cowboys


San Francisco 49ers / Arizona Cardinals -5 ½

Who knows if Jimmy Garoppolo will play? Even if Jimmy G. straps on the helmet, the 49ers are up against it versus the team with the best offense in the NFL. Kyler Murray, DeAndre Hopkins and the rest will feast on a San Francisco secondary decimated by injuries.

NFL Week 5 Pick:
Arizona Cardinals


Buffalo Bills +120 / Kansas City Chiefs

The Chiefs should be in some trouble. Josh Allen and the Bills are rolling. Buffalo averages 33.5 points from 404 yards per. So even though Patrick Mahomes and KC will score against Buffalo’s D, they shouldn’t keep up on the scoreboard.

NFL Week 5 Pick:
Buffalo moneyline


Monday, Oct. 11

Indianapolis Colts / Baltimore Ravens -7

The Colts are having issues on both sides of the football. But Baltimore heads into this after beating the Denver Broncos on the road. This game could be a trap for Lamar Jackson and the Ravens. That doesn’t mean they win. It does mean they will struggle to cover.

NFL Week 5 Pick:
Indianapolis Colts 

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