NFL Week 1 is Here: Dive into Our Expert Betting Lines Analysis

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Thanks to the recently released 2020 NFL schedule, football fans and betting aficionados across the globe are now eagerly awaiting the start of the new football season – coronavirus be damned!

With that thought in mind and a handful of intriguing matchups on tap for Week 1, let’s take a look at the best, must-see matchups on the opening slate of games and their NFL betting odds.

Week 1 NFL Games Analysis

Houston at Kansas City

The Texans won the AFC South last season, but head coach and now, GM Bill O’Brien as the architect behind the dumbest move of the offseason as he traded Pro Bowl wide receiver Deandre Hopkins for almost nothing. Sounds like a recipe for disaster against Patrick Mahomes and company if you ask me.

Date: Thursday, September 10

Seattle at Atlanta

Russell Wilson and the Seahawks have some legitimate Super Bowl hopes heading into 2020, but they’ll have to be on guard against Matt Ryan and a Falcons squad that won four straight and six of eight to close out the 2019 campaign.

Green Bay at Minnesota

Minnesota will be out for revenge in this one after getting swept by the Pack a year ago. Green Bay failed to give Aaron Rodgers any elite weapons this offseason and now, I believe the handwriting is on the all in this one!

Miami at New England

Miami smacked the Patriots around in their sensational 27-24 Week 17 road win over the Pats last season – and that was when New England had the incomparable Tom Brady under center.

Philadelphia at Washington

Washington made a great hire in naming former Panthers head coach Ron Rivera their new leading man while Philadelphia had one of the most perplexing drafts of any team in the league.

Indianapolis at Jacksonville

The Colts are turning to longtime former Chargers franchise signal-caller Philip Rivers to get them back in the postseason, but the Jaguars had a stupendous draft that was undeniably one of the best in the league this year.

Tampa Bay at New Orleans

Tom Brady and the revamped Tampa Bay Buccaneers are getting a ton of hype, but there’s this other future Hall of Famer lying in wait as Drew Brees and the high-scoring New Orleans Saints look to let everyone know they are the best team in the NFC South.

Date of the matches: Sunday, September 13

Tennessee at Denver

The Broncos are hoping that second-year Denver Broncos quarterback Drew Lock is the answer to their now, longstanding issues at quarterback. Denver’s stout defense will be severely tasted against powerful superstar running back Derrick Henry.

Date: Monday, September, 14

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It was a long wait until the first official Sunday of the 2022 NFL season, and although things started off a bit slow in week one, the league eventually showed why football is the most popular sport in the United States.

We had upsets, we had duds, and we even had a good old-fashioned tie (almost two of them). Here’s a week one recap so you can continue betting against the NFL Odds.

NFL Rumors, Trades, Free Agents & Betting News | September 12th Edition

Trouble in Green Bay?

He was missing two starting tackles, so there’s that excuse, but Aaron Rodgers had one of his worst games in recent memory, going 22/34 for 195 yards and an INT while also adding a fumble. The Packers lost 23-7 in Minnesota, but maybe there should be more concern with the Green Bay secondary that gave up a 9-catch, 184 yards, two TD day to the Vikings’ Justin Jefferson.

Upsets on the Menu

It can be hard for oddsmakers to set lines in week one because there’s nothing but preseason action to go off of, but they were clearly wrong in a few spots:

Bears beat 49ers – It was a rainy day in Chicago in a game with two relatively inexperienced QBs, but the Bears picked up an ugly 19-10 win over the 49ers as +6.5 home underdogs. Some would say San Francisco lost the game more than the Bears won it, but Chicago will still take the 1-0 start.

Steelers get the road win – Neither Pittsburgh nor Cincinnati seemed like they wanted this game; the Bengals had the game-winning extra point blocked with no time on the clock in regulation, and Chris Boswell’s 53-yard FG as time expired gave the Steelers a 23-20 road win as +7.5 underdogs

ltimately the win.

Week One Injuries

A couple of big-name players may be lost for an extended period of time after their week one injuries. Reigning defensive player of the year, T.J. Watt, couldn’t finish the team’s win over the Steelers, coming off the field with what looks like a torn pectoral injury that might have him out until December or January.

Dallas QB Dak Prescott will need surgery on his right thumb following the team’s anemic 19-3 loss to Tampa Bay on Sunday night. Prescott might not want to return with the way the Cowboys’ patchwork offensive line played, and indeed he will be out a reported six to eight weeks. Dallas now turns to Cooper Rush to run their offense, so it could be a long season in Dallas.

There were seven game-tying/go-ahead scores with under two minutes left in week one, so the parity definitely seems to be there in the NFL this season. We will see what week two brings.

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NFL teams will begin reporting to training camp in a little over a month and Week 1 of the regular season is less than three months away. One of the most interesting opening matchups is Cleveland at Carolina, with the Browns as 3-point favorites. here everything for your NFL Odds.

Betting Guide for NFL Week 1

Who will be the Browns’ starting quarterback? Baker Mayfield is still on the team but it’s only a matter of time before the former Heisman winner and No. 1 overall pick is traded – perhaps to the Panthers. Mayfield is owed just under $19 million for the 2022 season, and how much of his salary Cleveland is willing to pay has been a huge roadblock when it comes to potential trades. The latest rumors are that the Browns are willing to eat half his salary.

The Panthers continue to be a potential landing spot for Mayfield because of the uncertainty surrounding Sam Darnold, while the Seattle Seahawks — which are still figuring out their situation at QB between Drew Lock and Geno Smith — are also in the mix.

Of course, the Browns traded for Deshaun Watson this offseason and handed him the largest guaranteed contract in NFL history but there’s no way that Watson isn’t suspended for at least four games for all his off-field issues – he could be suspended the entire season. Two grand juries in Texas declined to indict Watson on criminal charges but the number of cases has since grown to 24. A league suspension could come soon for violation of its personal conduct policy.

Thus, the Week 1 starter likely will be Jacoby Brissett. Brissett came to the Browns after a season with the Miami Dolphins, in which he went 2-3 as a starter in place of Tua Tagovailoa. He completed 141-of-225 (62.7%) of his passes for 1,283 yards with five touchdowns and four interceptions.

“I do have confidence in Jacoby,” Coach Kevin Stefanski said during minicamp. “He has played a lot of football for a young player. He is a smart player. He takes care of the football. Good size, can make all of the throws and those type of things.”

The marquee game of Week 1 is the Thursday night Kickoff Game as the Buffalo Bills visit the Los Angeles Rams in a possible Super Bowl 57 preview. The Rams of course are defending Super Bowl champions. It’s the first time Buffalo and the Rams will take part in the league opening Thursday game.

It will be the first meeting between the two clubs since the 2020 season when the Bills beat the Rams in a barn burner of a game 35-32. Josh Allen threw a game-winning touchdown pass to Tyler Kroft with 15 seconds left in regulation. This game also marks the first for Buffalo free agent signing Von Miller in a Bills uniform. And Miller will do it against a Rams team he helped win a Super Bowl on their home field. The game is a pick’em.

The biggest Week 1 spread is Indianapolis giving 8 points at Houston in what will be the Colts debut of former Falcons quarterback Matt Ryan. In his final season with the Falcons, Ryan had 3,968 passing yards, 20 touchdowns and 12 interceptions. Ryan’s résumé is loaded with plenty of individual career success: 59,735 pass yards, 367 touchdowns, four Pro Bowls and 2016 NFL MVP.

For Coach Frank Reich, adjusting to a new quarterback is nothing new, because he has had a different Week 1 starter each season since he was hired by the Colts in 2018. Ryan had only three head coaches in his 14 seasons with the Falcons.

“I’ve really enjoyed spending time with [Reich] in the meeting room, getting a feel for his philosophy as a coach and the things that he believes in,” Ryan said. “Getting to know him as a person, you’re not going to find a better person than him. I really feel like we’ve made a lot of good strides in the last two months in terms of getting on the same page and communicating.”

Week 1 concludes on Monday night with Denver visiting Seattle in Russell Wilson’s return to the Pacific Northwest. Wilson wanted to win another Super Bowl, which is why he chose the Broncos in the first place. He wouldn’t have facilitated a trade to Denver if that wasn’t the case.

The Broncos are one of the prestigious franchises in the NFL, but their six-year playoff drought is the second-longest in the league. During the stretch, the Broncos have posted only one winning record (9-7 in 2016) and they are mired in a stretch of five straight losing seasons. Denver is a 4-point favorite. Seattle will have a training camp battle between Drew Lock and Geno Smith for its QB job.

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One of the marquee Week 1 matchups to kick off the 2021 NFL regular season is the Green Bay Packers at New Orleans Saints, but the game will not be played in New Orleans because of the damage the city suffered by the recent Hurricane Ida, which devastated most of Louisiana. It likely will be played at AT&T Stadium in Dallas on Sept. 12, an obvious break for the Packers. They are 3-point favorites on the NFL odds.

Week 1 matchups 2021 NFL regular season

Saints coach Sean Payton said this week that he doesn’t expect the team to return to New Orleans for the entirety of September. The entire Saints contingent is in Dallas currently and practicing there, and the stadium would be open on Sept. 12 because the Cowboys play on Sept. 9 in the Kickoff Game at the defending Super Bowl champion Tampa Bay Bucs.

The only events scheduled at AT&T Stadium in the next two weeks are the All-State Kickoff Classic featuring Kansas State and Stanford on Sept. 4 and the Latin band Los Bukis on Sept. 15.

“That’s certainly possible,” Cowboys owner Jerry Jones said this week about his stadium hosting Packers- Saints. “We’re having discussions. There’s a lot of moving parts, but we certainly have a kinship with the Saints because of our proximity to Louisiana. It’s a natural for us.”

Lambeau Field will be open that weekend, too, but Payton does not want to give the Packers homefield advantage for what is supposed to be a Saints’ home game. The Saints’ next two games are on the road vs. the Panthers (9/19) and Patriots (9/26). New Orleans next home game is scheduled for Oct. 3 against the New York Giants and there’s a good chance they could host that one.

While Caesars Superdome was not badly damaged, as it was by Hurricane Katrina 16 years ago, it may take New Orleans weeks to recover from Ida, which knocked out power to more than 1 million people in Louisiana and Mississippi.

New Orleans will be without Pro Bowl receiver Michael Thomas for the first six weeks as he will be placed on the PUP list following ankle surgery in June. Players on the PUP list cannot begin practicing until the first six weeks of the regular season have passed, but Thomas is required to miss only five games since the Saints have a bye in Week 6. The first game he could possibly play is at the Seattle Seahawks on Monday Night Football in Week 7.

Thomas missed a total of nine games last year after he originally suffered the ankle injury in the final minutes of Week 1. He finished with 40 catches for 438 yards in seven regular-season games and didn’t catch his first touchdown pass until the playoffs.

Green Bay will be without All-Pro left tackle David Bakhtiari, who also will open on the PUP list. Bakhtiari tore his ACL during practice on Dec. 31, knocking him out of the Packers’ postseason run. The five-time All-Pro — and the only tackle in the NFL to earn either first- or second-team recognition in each of the last five seasons (2016-2020) — was never likely to be ready for the season opener against the Orleans Saints. The Packers signed Bakhtiari to a four-year contract extension last November, putting him under contract through 2024.

The one glimmer of hope for the Packers is that Elgton Jenkins, who earned Pro Bowl honors as a guard last year, has looked good at left tackle in place of Bakhtiari this offseason. Jenkins is no stranger to the left tackle spot, having spent time there in both 2019 and 2020. Through his first two NFL seasons, Jenkins has shown he is one of the most versatile players not only in Green Bay but the entire league.

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We are now just a few days away from the opening preseason game of the NFL season. From this point forward, we are going to have football every Sunday until February, so it’s the perfect time to start looking ahead. Let’s start with Week 1 of the regular season and some picks that we like, keeping in mind that NFL odds and picks could change depending on how teams look at the end of the preseason.

NFL Week 1 Full Game Winning Picks and Predictions

Dallas Cowboys at Tampa Bay Buccaneers – The Buccaneers have covered the spread in each of their last 4 home games, so let’s take them at -6 ½.

Philadelphia Eagles at Atlanta Falcons – With changes to both teams, it’s tough to know what to expect. I am leaning towards the UNDER 48 here.

Pittsburgh Steelers at Buffalo Bills – Two very good defenses clash here. 5 of their last 6 meetings have gone UNDER, so let’s take that again.

Minnesota Vikings at Cincinnati Bengals – In this matchup, the favorite has covered 4 in a row, so let’s take the Vikings -3.

San Francisco 49ers at Detroit Lions – The 49ers have covered the spread in 7 of their last 10 Week 1 games. Let’s go with the 49ers at -7 ½.

Arizona Cardinals at Tennessee Titans – The Cardinals are 8-3-2 ATS in their last 13 games as a road dog. I’m taking them at +3.

Seattle Seahawks at Indianapolis Colts – It looks as though this one is off the board for now as we wait to see who will start for the Colts now that Carson Wentz is injured.

LA Chargers at Washington Football Team – Washington has seen 9 of their last 10 games played on grass go UNDER. Looks like a solid trend.

New York Jets at Carolina Panthers – In their last 4 meetings, the favorite has going 3-0-1 ATS, so let’s take the Panthers at -4.

Jacksonville Jaguars at Houston Texans – With the DeShaun Watson situation still up in the air, and the road team 13-6-1 ATS in the last 20, let’s take the Jags -3.

Cleveland Browns at Kansas City Chiefs – While I like the Chiefs to win here, the Browns have covered in 4 of the last 5 versus KC.

Miami Dolphins at New England Patriots – The Dolphins have only covered once in their last 9 visits to Foxboro, so let’s take the Patriots -2 ½.

Green Bay Packers at New Orleans Saints – The favorite has covered in 6 of the last 8 meetings between these two, so that would mean the Saints ATS here.

Denver Broncos at New York Giants – The Broncos have covered the spread in 4 of their last 5 games versus the Giants, so let’s take them again here.

Chicago Bears at LA Rams – A pair of teams with new QB’s. The UNDER has hit in 6 of the last 8 between these two.

Baltimore Ravens at Las Vegas Raiders – The Ravens offense is great, but the UNDER has hit in 6 of Raven’s last 7 games on the road.

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We are in the way too early phase to start making picks for the NFL season, but how awful would it be if we didn’t try at all? I am going to take a look at all the games in Week 1 to see if I can pick a few winners. While all the odds are up for the games, I am strictly going to stick with straight up picks at this time. We will get into more detail with point spread and O/U as the season gets closer. Let’s get right to the picks so you can get all set to bet against their NFL odds.

NFL Week 1 Picks – Early Predictions for Every Game

Dallas Cowboys at Tampa Bay Buccaneers – The Thursday night game on Week 1 will see the champs hoist their banner and kick things off against the Cowboys. I’m sticking with the Buccaneers at home.

Philadelphia Eagles at Atlanta Falcons – I’m not really sure what to expect from either of these teams this season, so this is tough. I am taking Atlanta to win a close one.

Pittsburgh Steelers at Buffalo Bills – The Bills come into the early season as one of the early favorites to win the Super Bowl, and while this is a tough start, I think they open the season with a win.

Minnesota Vikings at Cincinnati Bengals – It is going to be fun to see Joe Burrow back from injury, but I still think this is going to be a long season for the Bengals. I’m on Minnesota here.

San Francisco 49ers at Detroit Lions – The 49ers may still have some indecision at the QB spot, but they are miles ahead of Detroit and should get off to a winning start.

Arizona Cardinals at Tennessee Titans – I am looking at the Cardinals as a definite dark horse pick this season, but this is a tough opener. I have to go with the Titans at home.

Seattle Seahawks at Indianapolis Colts – The Colts look like a team ready to challenge in the AFC, but is Carson Wentz the man to lead them? I have Indy winning a tight one.

LA Chargers at Washington Football Team – This is another tough one, but if the Washington D is anything like it was last year, they might surprise a few teams. I’m taking them as a slight underdog.

New York Jets at Carolina Panthers – A pair of different QBs for each of these teams from last season. I have a little more faith in the Panthers here.

Jacksonville Jaguars at Houston Texans – No real word on the DeShaun Watson situation in Houston, which has me leaning towards the Jags in Week 1.

Cleveland Browns at Kansas City Chiefs – Two teams expected to be in the race to represent the AFC in the Super Bowl meet in Week 1. Gotta go with the Chiefs at Arrowhead.

Miami Dolphins at New England Patriots – This is another matchup that is tough to predict. I expect a close one, but I like the Patriots to eke out the win.

Green Bay Packers at New Orleans Saints – UGH!! I’m not really sure what to do here given the current Aaron Rodgers situation. Leaning towards the Saints, but that might change.

Denver Broncos at New York Giants – This is a bout as close to a pick ‘em play as it gets. I am taking a shot with the slight underdog and going with the Giants.

Chicago Bears at LA Rams – For me, the Rams look like a legitimate threat this season, which is why I have them opening with a win over the Bears.

Baltimore Ravens at Las Vegas Raiders – Speaking of threats, we also need to mention the Ravens. I think they open with a comfortable win on the road.

NFL Betting News

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Sometimes the best way to start your handicapping is to figure out which teams are sure to lose. With that in mind, check out a list of NFL squads that are almost guaranteed to lose their first game of the season. Let’s get right to it so you can continue planning your bets against their NFL odds.

Sure Losers for Week 1 of the 2021 NFL Regular Season

2021 NFL Season – Week 1

When: Thursday, Sep.9 – Monday, Sep.13

Sure NFL Losers for Week 1

Pittsburgh Steelers

The Steelers won’t be a terrible team, but because they’ve got the toughest schedule in the NFL, they may not win enough games to make the playoffs. A Week 1 loss is all but assured because Pittsburgh plays the Bills in Buffalo. NFL MVP favorite Josh Allen should dominate Pittsburgh’s defense.

Detroit Lions

One of the favorites to win the NFC, the San Francisco 49ers, head to Motor City to take on the Lions in Week 1. Detroit breaks in a new quarterback, Jared Goff, and is in rebuild mode. The Lions have no shot.

Seattle Seahawks

Surprised? Don’t be. Seattle has a big advantage with quarterback Russell Wilson. But the Colts aren’t in dire straits with Carson Wentz. More importantly, the Seahawks allowed 285 passing yards last season. Wentz should dominate the Hawks’ secondary.

New York Jets

In Week 1, the Jets face the Carolina Panthers and former quarterback Sam Darnold. Panthers’ coach Matt Rhule believes Darnold is the answer. If he’s right, Sam should light up a bad Jets’ defense. Yes, Zach Wilson should become a good pro. But he’s a rookie facing an underrated defense on the road in his first NFL start.

New England Patriots

Sure, New England takes on rival Miami at home. And, yes, the Patriots made some big changes on both offense and defense. But New England will either start Cam Newton or Mac Jones at quarterback. Jones is a rookie and Newton failed in 2020. Miami starts Tua Tagovailoa, who should play better in his second season because the Fins drafted one of Tua’s favorite targets at Alabama, Jaylen Waddle.

Green Bay Packers

Even if for some strange reason Aaron Rodgers and the Packers decide to get copasetic before the season starts, the Pack will fall to the Saints in Week 1. Sean Payton will have no trouble coaching Taysom Hill or Jameis Winston or both. The Saints’ defense should be just as good this season as last season, the offensive line didn’t change, and Alvina Kamara and Michael Thomas should both be one-hundred percent.

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National Football League teams head to training camps in July. Although it’s early, now’s the time to start preparing for NFL Week 1. Who knows? While preparing you might see an out of whack line that deserves a bet right now, today, well before the first NFL Preseason game. Check out a strategy that’s sure to help you handicap NFL Week 1 games as well future prop options. Let’s jump right into action so you can plan your bets against their NFL odds.

Optimal Handicapping Betting Strategy for Week 1 of the 2021 NFL Season

2021 NFL Season – Week 1

When: Thursday, Sep. 9 – Monday, Sep. 13

Top 4 NFL Week 1 Betting Strategies

Find overlays by selling the rumor and buying the news

“Sell the rumor and buy the news” is an old Wall Street saying. On Wall Street, investors love nothing more than to take advantage of amateurs who jump on the latest, greatest, investment vehicle like Bitcoin or GameStop stock.

The same thing happens in betting markets. For example, in NFL Week 1, the New England Patriots are -2 ½ favorites over the Miami Dolphins.

Now, maybe, after you handicap the game you’ll find that, yes, the Patriots should be favored. But before handicapping, think about it for a moment.

Miami’s quarterback is Tua Tagovailoa who already has experience starting in the NFL. The Patriots’ starting quarterback will be either Mac Jones, a rookie, or Cam Newton, who was awful last season.

The “rumor” is that Mac Jones looked great during mini-camp. Experienced NFL handicappers know that how a player looks during mini-camp, or even training camp, doesn’t always translate to how a player performs on Sundays.

Stick with 2020 NFL ATS winners

Teams that played well against the spread last year don’t always perform well against the spread the following year. In Week 1, though, the trend could hold.

Buffalo went 13-3 last year. They’re a -6 chalk against the Pittsburgh Steelers in Week 1. Miami went 11-5 ATS last season. We already know they’re a decent bet, at least right now, at +2 ½ versus the Patriots.

Consider coaching changes before player changes

Why is Jacksonville a -2 ½ favorite over the Houston Texans? Is it because Urban Meyer is their coach? Or is it because the Jaguars will start Trevor Lawrence at quarterback?

Either way, think about the coaching changes before player changes. The reason? Coaches set their team’s strategy.

So a coach like Texans’ HC David Culley, who has 27-years of experience in the NFL, may have an edge over Meyer. If you don’t believe us, think about the blowback Meyer and the Jaguars got for signing Tim Tebow to play tight-end.

Culley would have looked for a current NFL tight-end instead of signing someone who hasn’t played football in 2 years.

When in doubt, go with the better rushing team

This one is so obvious, we forget. The top rushing teams often outperform their opponents against the spread.

Other factors matter, of course. Don’t just blindly back the better rushing team. If nothing else affects your opinion, though, think about backing the team with a better ground attack.

Cleveland should end up a +6 underdog against the Chiefs in Week 1. The Browns are a much better rushing team. So think hard if Kansas City can cover the spread knowing the Browns will control the clock with their run game.

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Crazy weekend of trades and surprise roster moves around the NFL over the weekend, led by the Seattle Seahawks landing Texans defensive end Jadeveon Clowney, the former No. 1 overall pick. Yet Houston also got better by getting offensive lineman Laremy Tunsil and receiver Kenny Stills from Miami for draft picks. Here’s a look at every game on the Week 1 schedule, NFL odds and picks against the spread.

2019 NFL Week 1 Odds, Overview & Predictions

Green Bay at Chicago

NFL Week 1 Odds: Bears -3

Thursday night game. The Packers have largely dominated this series over the past decade but Chicago should have swept the Packers last year. They did win late in the season at Solider Field but blew a big third-quarter lead in Week 1 at Green Bay and lost. The Bears have covered their past seven games against NFC North foes and we think they do here. Pick: Bears.

Atlanta at Minnesota

NFL Week 1 Odds: Vikings -4

Two teams who disappointed last year but are good enough to win a Super Bowl this year is they stay healthy and catch the right breaks. Atlanta made a late change in the preseason at kicker in re-signing Matt Bryant to a one-year, $3 million deal. Bryant was released in February and went unsigned through training camp. The Falcons didn’t like what they saw from Giorgio Tavecchio and Blair Walsh this preseason. Atlanta has failed to cover the past four in the series. Pick: Vikings.

Washington at Philadelphia

NFL Week 1 Odds: Eagles -9.5

The Redskins aren’t likely going to be very good this year with Jay Gruden one of the favorites to be the first head coach fired. In a bit of a surprise, Gruden told reporters Monday that Derrius Guice will get more carries than Adrian Peterson this year. Guice missed all of last year with an injury. Pick: Redskins.

Buffalo at NY Jets (-3)

NFL Week 1 Odds: Jets -3

Pair of second-year quarterbacks face off in Josh Allen of Buffalo and Sam Darnold of the Jets. Both showed promising signs last year. Buffalo surprised many over the weekend in releasing veteran running back LeSean McCoy. That means rookie Devin Singletary likely will take over, although the team still has veterans Frank Gore and TJ Yeldon. Pick: Jets.

Baltimore at Miami

NFL Week 1 Odds: Ravens -7

Miami is probably the worst team in the NFL, especially after trading two starters, offensive tackle Laremy Tunsil and receiver Kenny Stills, to Houston over the weekend. The team also shipped out linebacker Kiko Alonso in a salary dump. The Fins are tanking my friends. Pick: Ravens.

San Francisco at Tampa Bay

NFL Week 1 Odds: PK

The 49ers have lost their past 12 games in the Eastern Time Zone. This will be the Bucs head coaching debut of Bruce Arians, the former Cardinals coach. Fifth-round rookie Matt Gay has won the Bucs’ kicking competition. Veteran Cairo Santos was released at final cuts Saturday. Pick: Bucs.

Kansas City at Jacksonville

NFL Week 1 Odds: Chiefs -4

Last year, the Chiefs beat the visiting Jaguars 30-14. Patrick Mahomes threw for 313 yards and ran for a score. The Chiefs defense picked off Blake Bortles four times and sacked him five. Kareem Hunt ran for 87 yards and a touchdown, and Travis Kelce hauled in five catches for 100 yards. Hunt’s gone now. Pick: Jaguars.

Tennessee at Cleveland

NFL Week 1 Odds: Browns -5.5

The Browns are a chic pick to win reach the first Super Bowl in franchise history this season; they are one of four active franchises to never make the game. The Titans have failed to cover the past four in this series. Pick: Browns.

LA Rams at Carolina

NFL Week 1 Odds: Rams -3

The Panthers will have quarterback Cam Newton. He injured his foot in Week 3 of the preseason but is good to go. For Newton, battling through injuries has become the norm. While he’s only missed five games in his career, he’s dealt with ankle issues, a fractured rib, a broken back suffered in a car accident, a torn rotator cuff and shoulder ailments in general. Pick: Panthers.

Cincinnati at Seattle

NFL Week 1 Odds: Seahawks -9.5

Top Bengals receiver AJ Green will miss this game and probably at least a few more. He’s still in a walking boot. The 31-year-old Green missed seven games last year and had career lows of 46 catches for 694 yards. He’s heading into the final year of his contract. Pick: Bengals.

Indianapolis at LA Chargers

NFL Week 1 Odds: Chargers -6.5

This matchup looked like one of the best of Week 1 until the Colts saw star QB Andrew Luck retire. The Chargers, meanwhile, remain without Pro Bowl running back Melvin Gordon as he continues his holdout. Indy is 2-7 ATS in the past nine meetings. Pick: Chargers.

Detroit at Arizona

NFL Week 1 Odds: Lions -2.5

It’s the NFL debut of Cardinals quarterback Kyler Murray, last year’s Heisman Trophy winner at Oklahoma.

New Cardinals head coach Kliff Kingsbury believes Murray will be the perfect quarterback to lead his air raid offensive system. The Cards are just 1-4 ATS in their past five at home. Pick: Lions.

NY Giants at Dallas

NFL Week 1 Odds: Cowboys -7

Will the Cowboys have star running back Ezekiel Elliott? He continues to hold out for a new contract but the sides reportedly are close to a deal. If it doesn’t happen in the next 24 hours, it will be hard to envision Elliott being ready to play by Sunday. The Giants have failed to cover the past four in the series. Pick: Cowboys.

Pittsburgh at New England

NFL Week 1 Odds: Patriots -5.5

Sunday night game. New England’s last loss in a game that counted was Week 15 of last season, 17-10 in Pittsburgh. Jaylen Samuels rushed for a career-high 142 yards for the Steelers. The Steelers had dropped five straight to New England and only beaten Tom Brady twice in his storied career. Pick: Patriots.

Houston at New Orleans

NFL Week 1 Odds: Saints -7

First Monday night game. Could be a Super Bowl preview, especially as Houston got better over the weekend with the trades for Miami’s Tunsil and Stills. Tunsil will protect Deshaun Watson’s backside, while Stills will immediately slot in as the No. 3 wideout behind DeAndre Hopkins and Will Fuller. Pick: Saints.

Denver at Oakland (pick’em)

NFL Week 1 Odds: PK

Second Monday night game. It’s the Broncos debut of quarterback Joe Flacco and coach Vic Fangio. It’s the Oakland debut of former Steelers All-Pro receiver Antonio Brown. Pick: Broncos.

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The 2019-2020 NFL Regular Season starts on Thursday, September 5, when the Chicago Bears host the rival Green Bay Packers. September 5 sounds like a long way from now. It’s not! Check out a complete betting guide to NFL Week 1!

2019 NFL Week 1 Complete Betting Guide

Really consider the big change that some NFL squads went through

Some big changes will help teams cover the spread in Week 1. Other changes might hurt a team’s chances to cover the spread. Let’s take Packers-Bears as an example.

Chicago is a -3 ½ home favorite. The Bears are one of the betting choices to win the Super Bowl. Green Bay is the second choice to win the NFC North Division after Chicago. The Packers went through, arguably, the biggest change of the offseason when former L.A. Rams and Tennessee Titans offensive coordinator Matt LaFleur became their head coach.

Will LaFleur’s system flatter quarterback Aaron Rodgers? How will Rodgers play against Chicago with the new system?

Those are the questions to ask. Think about another team that went through a massive change, the Tampa Bay Buccaneers. Tampa is a -1 home favorite versus San Francisco in Week 1. Tampa Bay’s new head coach, Bruce Arians, turned the Arizona Cardinals into an NFC West contender. Arians has made big moves already. He wants to put his stamp on the Bucs. Does that mean Tampa is vulnerable in Week 1? Or, does that mean Arians makes Tampa Bay a contender right away?

Don’t discount NFL squads that stayed consistent

Consistent NFL teams should prevail against the spread in Week 1. The New Orleans Saints battle the Houston Texans in Week 1 as a -7 home favorite. That seems like a lot of points, but the Saints are a cover darling. They have been for the past couple of seasons. They should cover again.

The Patriots take on the Pittsburgh Steelers as a -6 favorite. Talk about big changes! The Steelers will play for the first time in years without wide receiver Antonio Brown and running back Le’Veon Bell. New England, even without Rob Gronkowski, has the edge.

Going back to Green Bay versus Chicago, the Bears should have the edge based on consistency. LaFleur’s offensive system isn’t easy to grasp. Rodgers will do it, but unless his supporting cast does as well, forget it. The Bears should cover.

NFL Week 1 Full Betting Game Guide

Check out a full run down of the NFL Week 1 games!

Previous Betting News

Are you ready for some football?! We here at Mybookie Sportsbook sure are. Get up to a $1,000 sign-up bonus to get your bankroll started for the NFL season. Here’s a quick glance at every NFL Week 1 Odds alongside some predictions.

2018 NFL Week 1 Odds & Predictions for Each Game

NFL Week 1 Odds: (-2.5)

The annual Thursday night Kickoff Game, which the defending Super Bowl champions have largely dominated. However, that wasn’t the case last year as the New England Patriots were stunned at home as heavy favorites against the Kansas City Chiefs.

The Eagles won’t have either star quarterback Carson Wentz or No. 1 receiver Alshon Jeffery for this one. Thus, we’ll take Atlanta to avenge last season’s Divisional Round loss in Philly.

Pittsburgh Steelers at Cleveland Browns

NFL Week 1 Odds: (+6)

Cleveland enters on a 16-game losing streak and almost never beats Ben Roethlisberger. The Steelers QB is 22-2 in his career against the team he grew up rooting for.

The Steelers also will have the services of RB Le’Veon Bell after he sat out the preseason before signing his franchise tag. Go Pittsburgh even though Cleveland will be a lot better this year.

San Francisco 49ers at Minnesota Vikings

NFL Week 1 Odds: (-6)

It’s the Minnesota debut (in a game that counts) of quarterback Kirk Cousins, the biggest offseason free-agent signing on the market. The 49ers are a chic playoff pick after winning their final five games last year under rising star QB Jimmy Garoppolo. Bet Vikings.

Cincinnati Bengals at Indianapolis Colts

NFL Week 1 Odds: (-3)

It’s Andrew Luck’s first regular-season game since Week 17 of the 2016 season. The Bengals are without top linebacker Vontaze Burfict do to suspension. Still like Cincinnati.

Buffalo Bills at Baltimore Ravens

NFL Week 1 Odds: (-7)

Coach Sean McDermott chooses Nathan Peterman over Josh Allen as the Buffalo Bills starting QB. Don’t forget AJ McCarron was traded to Oakland, so there’s no experimented backup at all. Go Ravens.

Jacksonville Jaguars at NY Giants

NFL Week 1 Odds: (+3)

The Jaguars are road favorites!? What year is this? It’s our first look at the NFL Offensive Rookie of the Year favorite, Giants running back Saquon Barkley. He barely played in the preseason due to injury. Go with the Giants.

Tampa Bay Buccaneers at New Orleans Saints

NFL Week 1 Odds: (-10)

Biggest spread on the board because the Bucs are without suspended starting QB Jameis Winston. The Saints, though, are without starting running back Mark Ingram. They’ll win but that’s too many points.

Houston Texans at New England Patriots

NFL Week 1 Odds: (-6.5)

Per usual, the Patriots enter the season as Super Bowl favorites. Houston welcomes back QB Deshaun Watson, so good as a rookie before hurting his knee. Take Pats.

Tennessee Titans at Miami Dolphins

NFL Week 1 Odds: (+1.5)

Miami probably isn’t going to be very good this season. The Titans might take a step back after making the playoffs last season. Go with the home side.

Kansas City Chiefs at LA Chargers

NFL Week 1 Odds: (-3.5)

Now we find out if Kansas City was wise to trade away QB Alex Smith and hand things over to young Patrick Mahomes. The Chiefs have won eight straight in series but that ends here.

Seattle Seahawks at Denver Broncos

NFL Week 1 Odds: (-3)

It’s the Denver debut of Case Keenum, who helped lead Minnesota to last season’s NFC title game but was cast aside. The Seahawks seem to be a team in transition with the Legion of Boom broken up.

Hawks could be one of NFL’s worst teams if Russell Wilson were to get hurt. Take Denver.

Dallas Cowboys at Carolina Panthers

NFL Week 1 Odds: (-3)

Hard to know what to think of the Cowboys this year. Are they as good as they were in 2016 when they were 13-3? Probably not. A 9-7 team like last year? Hard to say.

They are a bit banged up on the offensive line. The Panthers go as Cam Newton goes. Go Panthers.

Washington Redskins at Arizona Cardinals

NFL Week 1 Odds: (pick’em)

Alex Smith makes his Redskins debut under center. So does Sam Bradford for Arizona, although it’s only a matter of time before he gets hurt because he always does. This is the only pick’em on the board. Take the Cards.

Chicago Bears at Green Bay Packers

NFL Week 1 Odds: (-8)

The Sunday night game and NFL’s oldest rivalry. The Bears stunned the NFL over the weekend by trading for Raiders star end/linebacker Khalil Mack, the 2016 NFL Defensive Player of the Year.

That won’t be enough to beat Green Bay but Chicago can hang within a TD.

NY Jets at Detroit Lions

NFL Week 1 Odds: (-6.5)

The Jets’ Sam Darnold becomes the NFL’s youngest-ever Week 1 starting quarterback. Alas, I don’t think it’s going to go well for him in Motown. Take the Lions.

LA Rams at Oakland Raiders

NFL Week 1 Odds: (+4.5)

No way the Raiders are better than they were before trading Khalil Mack to Chicago. The Rams are a chic pick to win the Super Bowl and are absolutely loaded. They win.

Previous Betting News

As of this writing, there are only 72 days until the 2017 NFL season kicks off! Teams will start reporting to training camps in just a few weeks. No reason to wait, however, as you can bet on NFL Week 1 games right now at MyBookie – although lines will certainly change should there be a major injury. Here are some notes for Week 1.

Complete NFL Week 1 Betting Guide for 2017 Season

Biggest Spread & Total

First of all, NFL Week 1 kicks off on Thursday, Sept. 7 with New England at -7.5 vs. Kansas City. The Patriots last hosted the Chiefs in the divisional round of the playoffs after the 2015 regular season. New England posted a 27-20 victory in that game, with tight end Rob Gronkowski’s two touchdown receptions helping the Patriots open a 21-6 lead in the third quarter in a game in which they weren’t really threatened.

Another storyline will be commissioner Roger Goodell’s presence at the game. He hasn’t been to a New England home game since Deflategate. The biggest opening line favorites for Week 1 are the Pittsburgh Steelers who opened as 9-point chalk on the road against the Cleveland Browns.

The highest total on the early betting board is between the Oakland Raiders and the Tennessee Titans, which opened at 52.5.

What Happened the Last Time Oakland and Tennessee Met?

Oakland played at Tennessee in Week 3 last year and won 17-10. Derek Carr threw for 249 yards and a touchdown. Oakland took control in the second quarter, scoring 10 points and outgaining the Titans 129-40 to take a 17-3 lead into halftime. Carr recently became the NFL’s highest-paid player, signing a five-year, $125 million extension.

Despite missing the 2017 regular-season finale, Carr finished tied for third in NFL MVP voting. He passed for 3,937 yards with 28 TD passes, six interceptions and set an NFL record with five winning touchdown passes in the fourth quarter or overtime last season.

Debuting On New Teams

Some big-name free agents changed teams this offseason. Perhaps the biggest is the greatest running back in Vikings history, Adrian Peterson. He signed with the New Orleans Saints… who opens 2017 at Minnesota.

Minnesota are 3.5-point NFL betting favorites. Peterson is 32 and coming off a meniscus injury that sidelined him for three months last season — and limited him to just 37 carries, a 1.9 yards-per-carry average and zero touchdowns. During offseason workouts, Peterson’s new teammates were amazed at him.

“He’s a stud, man. He looks the part,” Saints quarterback Drew Brees. “There’s something about handing the ball off to that guy and watching him run through the hole and take on anybody who tries to tackle him.” Peterson, though, isn’t even expected to be the featured back. That would be Mark Ingram.

Was Adrian Peterson Used Much in Minnesota?

The Vikings didn’t use Peterson much out of the backfield in recent years but says he can be a weapon in that regard. Peterson — who has 11,747 career rushing yards and 97 rushing touchdowns vs. 1,945 receiving yards and five receiving TDs – said that he just wasn’t used in that role much with the Minnesota Vikings.

But he pointed out that he had his two best receiving seasons in the two years that he played with quarterback Brett Favre (436 yards in 2009 and 341 in 2010). “So it's all about having a guy that’s gonna get the ball to you. And without a doubt, I know Brees will be doing that,” Peterson said.

Other big names moving were Marshawn Lynch from retirement/Seahawks to Oakland, the Saints trading Brandin Cooks to New England, the Eagles signing Alshon Jeffrey and LeGarrett Blount, and the Redskins signing Terrelle Pryor.

Who Will Be Browns QB?

Since the Cleveland Browns returned to the NFL in 1999, they have started an amazing 26 quarterbacks. Who will it be in Week 1 against Pittsburgh? That’s to be determined There are three guys, none of whom would seem to have a huge advantage. Second-year Cody Kessler knows the system and seems intent on improving.

Trade addition Brock Osweiler is a mystery and was awful last year in Houston. DeShone Kizer is the draft pick who has a lot of work to do. Kizer took a lot of his reps with the starters during OTAs and minicamp, so he must be a real threat to be the starter for the Browns when they open up the season.

Taken in the 2nd round of this year’s draft, Kizer was the 52nd overall pick. Looking at all four quarterbacks on the roster, that makes Kizer the highest pick on the team, since Osweiler was taken 57th overall back in 2012 by the Denver Broncos. Kessler was a third-round pick last year.

Will Cody Kessler Be the Starting QB?

“What I see in him is a big, strong, guy which is defined in this division by Ben [Roethlisberger] and by Joe Flacco, and this kid’s in that mold,” said QBs coach David Lee. “He’s 6-4 3/4, he’s got a 10-inch hand, he’s smart, he can run, he move.”

Last season, Coach Hue Jackson was quick to name Robert Griffin III the starter, but he might take a little more time to name the starter this year. I believe it will be Kessler in Week 1

Upcoming NFL Week 1 Schedule

Thursday, September 7th

Kansas City Chiefs at New England Patriots. 8:30pm ET. NFL Odds: Patriots at -7½

Sunday, September 10th

Monday, September 11th

New Orleans Saints at Minnesota Vikings. 7:10pm ET. NFL Odds: Vikings at -3½
LA Chargers at Denver Broncos. 10:10pm ET. NFL Odds: Broncos at -3½

Final NFL Week 1 Betting Predictions

With the time frame that’s left for the season to start, much can change and the odds can vary as well. The preseason will give us an idea where the teams are focusing on this year. But until then, be sure to check out upcoming NFL Week 1 game previews and predictions within the following weeks leading to the 2017 season. Lastly, start getting ready for a great season.