Explore the NFL top betting Week 5 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Five
Top NFL Week 5 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 5: Thursday, October 2nd – Monday, October 6th, 2025
BYE WEEK: Falcons, Bears, Packers, Steelers
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NFL Football Lines Week Five
Betting 2025 NFL Week 5 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Oct 2 – Totals TBA
49ers Spread TBA, Winner TBA
Rams Spread TBA, Winner TBA
Oct 5 – Totals O/U TBA
Vikings Spread TBA, Winner TBA
Browns Spread TBA, Winner TBA
Oct 5 – Totals O/U TBA
Texans Spread TBA, Winner TBA
Ravens Spread TBA, Winner TBA
Oct 5 – Totals TBA
Dolphins Spread TBA, Winner TBA
Panthers Spread TBA, Winner TBA
Oct 5 – Totals TBA
Raiders Spread TBA, Winner TBA
Colts Spread TBA, Winner TBA
Oct 5 – Totals TBA
Giants Spread TBA, Winner TBA
Saints Spread TBA, Winner TBA
Oct 5 – Totals O/U TBA
Cowboys Spread TBA, Winner TBA
Jets Spread TBA, Winner TBA
Oct 5 – Totals O/U TBA
Broncos Spread TBA, Winner TBA
Eagles Spread TBA, Winner TBA
Oct 5 – Totals O/U 48.5
Titans Spread -2.5, Winner -152
Cardinals Spread +2.5, Winner +119
Oct 5 – Totals O/U TBA
Buccaneers Spread TBA, Winner TBA
Seahawks Spread TBA, Winner TBA
Oct 5 – Totals O/U TBA
Lions Spread TBA, Winner TBA
Bengals Spread TBA, Winner TBA
Oct 5 – Totals O/U TBA
Commanders Spread TBA, Winner TBA
Chargers Spread TBA, Winner TBA
Oct 5 – Totals O/U TBA
Patriots Spread TBA, Winner TBA
Bills Spread TBA, Winner TBA
Oct 6 – Totals O/U TBA
Chiefs Spread TBA, Winner TBA
Jaguars Spread TBA, Winner TBA
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
