Explore the NFL top betting Week 5 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Five
Top NFL Week 5 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 5: Thursday, October 2nd – Monday, October 6th, 2025
BYE WEEK: Falcons, Bears, Packers, Steelers
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NFL Football Lines Week Five
Betting 2025 NFL Week 5 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu. Oct. 2, 8:15 PM EDT | 49ers at Rams | 49ers TBA; Rams TBA | TBA |
| Sun, Oct. 5, 9:30 AM EDT | Vikings at Browns | Vikings TBA; Browns TBA | TBA |
| Sun, Oct. 5, 1:00 PM EDT | Texans at Ravens | Texans TBA; Ravens TBA | TBA |
| Sun. Oct. 5, 1:00 PM EDT | Dolphins at Panthers | Dolphins TBA; Panthers TBA | TBA |
| Sun, Oct. 5, 1:00 PM EDT | Raiders at Colts | Raiders TBA; Colts TBA | TBA |
| Sun. Oct. 5, 1:00 PM EDT | Giants at Saints | Giants TBA; Saints TBA | TBA |
| Sun, Oct. 5, 1:00 PM EDT | Cowboys at Jets | Cowboys TBA; Jets TBA | TBA |
| Sun. Oct. 5, 1:00 PM EDT | Broncos at Eagles | Broncos TBA; Eagles TBA | TBA |
| Sun, Oct. 5, 4:05 PM EDT | Titans at Cardinals | Titans TBA; Cardinals TBA | TBA |
| Sun. Oct. 5, 4:05 PM EDT | Buccaneers at Seahawks | Buccaneers TBA; Seahawks TBA | TBA |
| Sun, Oct. 5, 4:25 PM EDT | Lions at Bengals | Lions TBA; Bengals TBA | TBA |
| Sun. Oct. 5, 4:25 PM EDT | Commanders at Chargers | Commanders TBA; Chargers TBA | TBA |
| Sun, Oct. 5, 8:20 PM EDT | Patriots at Bills | Patriots TBA; Bills TBA | TBA |
| Mon. Oct. 6, 8:15 PM EDT | Chiefs at Jaguars | Chiefs TBA; Jaguars TBA | TBA |
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
