Explore the NFL top betting Week 10 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Ten
Top NFL Week 10 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 10: Thursday, November 6th – Monday, November 10th, 2025
BYE WEEK: Bengals, Cowboys, Chiefs, Titans
Key Games to Watch and Bet
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NFL Football Lines Week Ten
Betting 2025 NFL Week 10 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Nov 6 – Totals 43
Raiders Spread +9, Winner +374
Broncos Spread -9, Winner -510
Nov 9 – Totals O/U 48.5
Falcons Spread +6, Winner +215
Colts Spread -6, Winner -291
Nov 9 – Totals O/U 37.5
Browns Spread -2.5, Winner -148
Jets Spread +2.5, Winner +116
Nov 9 – Totals 40
Saints Spread +5.5, Winner +195
Panthers Spread -5.5, Winner -260
Nov 9 – Totals 50
Bills Spread -9.5, Winner -542
Dolphins Spread +9.5, Winner +368
Nov 9 – Totals 38
Jaguars Spread +1, Winner -105
Texans Spread -1, Winner -121
Nov 9 – Totals O/U 47.5
Giants Spread +3.5, Winner +154
Bears Spread -3.5, Winner -200
Nov 9 – Totals O/U 49
Ravens Spread -4, Winner -224
Vikings Spread +4, Winner +171
Nov 9 – Totals O/U 48.5
Patriots Spread +2.5, Winner +117
Buccaneers Spread -2.5, Winner -149
Nov 9 – Totals O/U 45.5
Cardinals Spread +6.5, Winner +240
Seahawks Spread -6.5, Winner -336
Nov 9 – Totals O/U 49.5
Lions Spread -9.5, Winner -461
Commanders Spread +9.5, Winner +320
Nov 9 – Totals O/U 50
Rams Spread -4, Winner -210
49ers Spread +4, Winner +162
Nov 9 – Totals O/U 45
Steelers Spread +3, Winner +125
Chargers Spread -3, Winner -160
Nov 10 – Totals O/U 45
Eagles Spread +2.5, Winner +112
Packers Spread -2.5, Winner -143
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About the Author
Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
