NFL Top Betting Week 16 Odds: Do or Die Matchups for Playoffs and Profits

Written by on August 1, 2025

Explore the NFL top betting Week 16 odds at MyBookie for insights, strategies and updates to enhance your game day experience.

 

NFL Football Lines Week Sixteen
Top NFL Week 16 Matchups to Watch

2025 NFL Season | 106th season of the National Football League
Week 16: Thursday, December 18th – Monday, December 22nd, 2025
BYE WEEK: No teams on bye.

 

Key Games to Watch and Bet

So, what are you waiting for?
Head over to our NFL betting lines now and Sign Up for an Account to bet on all the matchups of Week 16 and the rest of the season, you’re sure to find the perfect wager to add some extra excitement to your NFL viewing experience!

 
NFL Bonus
NFL top betting Week 16 odds

 
 

NFL Football Lines Week Sixteen

Betting 2025 NFL Week 16 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change

Dec 18 – Totals TBA
Rams Spread TBA, Winner TBA
Seahawks Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Patriots Spread TBA, Winner TBA
Ravens Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Buccaneers Spread TBA, Winner TBA
Panthers Spread TBA, Winner TBA

Dec 21 – Totals TBA
Bills Spread TBA, Winner TBA
Browns Spread TBA, Winner TBA

Dec 21 – Totals TBA
Chargers Spread TBA, Winner TBA
Cowboys Spread TBA, Winner TBA

Dec 21 – Totals TBA
Jets Spread TBA, Winner TBA
Saints Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Vikings Spread TBA, Winner TBA
Giants Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Chiefs Spread TBA, Winner TBA
Titans Spread TBA, Winner TBA

Dec 21 – Totals O/U 48.306
Falcons Spread TBA, Winner TBA
Cardinals Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Jaguars Spread TBA, Winner TBA
Broncos Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Steelers Spread TBA, Winner TBA
Lions Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Raiders Spread TBA, Winner TBA
Texans Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
Bengals Spread TBA, Winner TBA
Dolphins Spread TBA, Winner TBA

Dec 21 – Totals O/U TBA
49ers Spread TBA, Winner TBA
Colts Spread TBA, Winner TBA

TBA – Totals O/U TBA
Packers Spread TBA, Winner TBA
Bears Spread TBA, Winner TBA

TBA – Totals O/U TBA
Eagles Spread TBA, Winner TBA
Commanders Spread TBA, Winner TBA

 

Elevate your NFL Season with MyBookie + Loyalty Rewards Program

Start to earn points with the Sportsbook and Casino Loyalty Program to level up, get exclusive bonuses and rakeback in every stage of the 2025/26 Season: Draft, Offseason, Preseason, Regular Season, Playoffs and Super Bowl.

Join the MyBookie program, subscribing will guarantee your share of $15,000 in free plays.

Bet On NFL top betting odds, anywhere, anytime

 

NFL Betting News

Complement your betting plans with NFL betting news, rumors, trends and everything you need to know for the 2025/26 NFL season that comes loaded with opportunities to win with top teams in all Divisions, Conferences AFC, NFC and the Super Bowl.

 
 

All NFL Teams to Win

 
 
 

About the Author

MyBookie's Expert Writer
  • D.S. Williamson
  • Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.