Explore the NFL top betting Week 15 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Fifteen
Top NFL Week 15 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 15: Thursday, December 11th – Monday, December 15th, 2025
BYE WEEK: No teams on bye.
Key Games to Watch and Bet
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NFL Football Lines Week Fifteen
Betting 2025 NFL Week 15 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Dec 11 – Totals 44.5
Falcons Spread +4, Winner +172
Buccaneers Spread -4, Winner -214
Dec 14 – Totals 42.5
Cardinals Spread +10, Winner +370
Texans Spread -10, Winner -549
Dec 14 – Totals 41.5
Jets Spread +12.5, Winner +550
Jaguars Spread -12.5, Winner -1000
Dec 14 – Totals O/U 49.5
Bills Spread +1, Winner -111
Patriots Spread -1, Winner -115
Dec 14 – Totals 41.5
Chargers Spread +4.5, Winner +180
Chiefs Spread -4.5, Winner -236
Dec 14 – Totals O/U 51.5
Ravens Spread -2.5, Winner -158
Bengals Spread +2.5, Winner +124
Dec 14 – Totals O/U 47
Commanders Spread +2.5, Winner +107
Giants Spread -2.5, Winner -136
Dec 14 – Totals O/U 39.5
Browns Spread +7.5, Winner +300
Bears Spread -7.5, Winner -429
Dec 14 – Totals O/U 38.5
Raiders Spread +11, Winner +530
Eagles Spread -11, Winner -901
Dec 14 – Totals O/U 40.5
Panthers Spread -2.5, Winner -154
Saints Spread +2.5, Winner +120
Dec 14 – Totals O/U 43.5
Packers Spread -2.5, Winner -136
Broncos Spread +2.5, Winner +106
Dec 14 – Totals O/U 42.5
Colts Spread +13.5, Winner +582
Seahawks Spread -13.5, Winner -1033
Dec 14 – Totals O/U 44.5
Titans Spread +13, Winner +550
49ers Spread -13, Winner -952
Dec 14 – Totals O/U 55
Lions Spread +5.5, Winner +210
Rams Spread -5.5, Winner -283
Dec 14 – Totals O/U 47.5
Vikings Spread +6, Winner +202
Cowboys Spread -6, Winner -265
Dec 15 – Totals O/U 41.5
Dolphins Spread +3.5, Winner +150
Steelers Spread -3.5, Winner -194
Week Sixteen >>
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
