Discover the NFL top betting Week 6 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Six
Top NFL Week 6 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 6: Thursday, October 9th – Monday, October 13th, 2025
BYE WEEK: Texans, Vikings
Key Games to Watch and Bet
So, what are you waiting for?
Head over to our NFL betting lines now and Sign Up for an Account to bet on all the matchups of Week 6 and the rest of the season, you’re sure to find the perfect wager to add some extra excitement to your NFL viewing experience!
NFL Football Lines Week Six
Betting 2025 NFL Week 6 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Oct 9 – Totals TBA
Eagles Spread TBA, Winner TBA
Giants Spread TBA, Winner TBA
Oct 12 – Totals O/U TBA
Broncos Spread TBA, Winner TBA
Jets Spread TBA, Winner TBA
Oct 12 – Totals O/U TBA
Rams Spread TBA, Winner TBA
Ravens Spread TBA, Winner TBA
Oct 12 – Totals TBA
Cowboys Spread TBA, Winner TBA
Panthers Spread TBA, Winner TBA
Oct 12 – Totals TBA
Cardinals Spread TBA, Winner TBA
Colts Spread TBA, Winner TBA
Oct 12 – Totals TBA
Seahawks Spread TBA, Winner TBA
Jaguars Spread TBA, Winner TBA
Oct 12 – Totals O/U TBA
Chargers Spread TBA, Winner TBA
Dolphins Spread TBA, Winner TBA
Oct 12 – Totals O/U TBA
Browns Spread TBA, Winner TBA
Steelers Spread TBA, Winner TBA
Oct 12 – Totals O/U 48.12
49ers Spread -2.12, Winner -1122
Buccaneers Spread +2.12, Winner +119
Oct 12 – Totals O/U TBA
Titans Spread TBA, Winner TBA
Raiders Spread TBA, Winner TBA
Oct 12 – Totals O/U TBA
Bengals Spread TBA, Winner TBA
Packers Spread TBA, Winner TBA
Oct 12 – Totals O/U TBA
Patriots Spread TBA, Winner TBA
Saints Spread TBA, Winner TBA
Oct 12 – Totals O/U TBA
Lions Spread TBA, Winner TBA
Chiefs Spread TBA, Winner TBA
Oct 13 – Totals O/U TBA
Bills Spread TBA, Winner TBA
Falcons Spread TBA, Winner TBA
Oct 13 – Totals O/U TBA
Bears Spread TBA, Winner TBA
Commanders Spread TBA, Winner TBA
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
