Discover the NFL top betting Week 6 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Six
Top NFL Week 6 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 6: Thursday, October 9th – Monday, October 13th, 2025
BYE WEEK: Texans, Vikings
Key Games to Watch and Bet
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NFL Football Lines Week Six
Betting 2025 NFL Week 6 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Oct 9 – Totals 40.5
Eagles Spread -7, Winner -407
Giants Spread +7, Winner +304
Oct 12 – Totals O/U 43.5
Broncos Spread -7.5, Winner -443
Jets Spread +7.5, Winner +310
Oct 12 – Totals O/U 38
Browns Spread +5.5, Winner +204
Steelers Spread -5.5, Winner -275
Oct 12 – Totals 47.5
Cardinals Spread +6.5, Winner +249
Colts Spread -6.5, Winner -343
Oct 12 – Totals O/U 44.5
Rams Spread -7.5, Winner -403
Ravens Spread +7.5, Winner +291
Oct 12 – Totals 46.5
Seahawks Spread +1.5, Winner -103
Jaguars Spread -1.5, Winner -124
Oct 12 – Totals 49.5
Cowboys Spread -3.5, Winner -179
Panthers Spread +3.5, Winner +139
Oct 12 – Totals O/U 43
Chargers Spread -4, Winner -222
Dolphins Spread +4, Winner +170
Oct 12 – Totals O/U 46
Patriots Spread -3.5, Winner -196
Saints Spread +3.5, Winner +151
Oct 12 – Totals O/U 41
Titans Spread +4.5, Winner +177
Raiders Spread -4.5, Winner -232
Oct 12 – Totals O/U 47.5
49ers Spread +3, Winner +125
Buccaneers Spread -3, Winner -160
Oct 12 – Totals O/U 44.5
Bengals Spread +14.5, Winner +788
Packers Spread -14.5, Winner -1683
Oct 12 – Totals O/U 52.5
Lions Spread +2, Winner +112
Chiefs Spread -2, Winner -142
Oct 13 – Totals O/U 49.5
Bills Spread -4.5, Winner -216
Falcons Spread +4.5, Winner +166
Oct 13 – Totals O/U 49
Bears Spread +4.5, Winner +171
Commanders Spread -4.5, Winner -224
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
