NFL Top Betting Week 6 Odds: All the Matchups for the Week

Written by on August 1, 2025

Discover the NFL top betting Week 6 odds at MyBookie for insights, strategies and updates to enhance your game day experience.

 

NFL Football Lines Week Six
Top NFL Week 6 Matchups to Watch

2025 NFL Season | 106th season of the National Football League
Week 6: Thursday, October 9th – Monday, October 13th, 2025
BYE WEEK: Texans, Vikings

 

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NFL top betting Week 6 odds

   
 

   

NFL Football Lines Week Six

Betting 2025 NFL Week 6 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change

Oct 9 – Totals 40.5
Eagles Spread -7, Winner -407
Giants Spread +7, Winner +304

Oct 12 – Totals O/U 43.5
Broncos Spread -7.5, Winner -443
Jets Spread +7.5, Winner +310

Oct 12 – Totals O/U 38
Browns Spread +5.5, Winner +204
Steelers Spread -5.5, Winner -275

Oct 12 – Totals 47.5
Cardinals Spread +6.5, Winner +249
Colts Spread -6.5, Winner -343

Oct 12 – Totals O/U 44.5
Rams Spread -7.5, Winner -403
Ravens Spread +7.5, Winner +291

Oct 12 – Totals 46.5
Seahawks Spread +1.5, Winner -103
Jaguars Spread -1.5, Winner -124

Oct 12 – Totals 49.5
Cowboys Spread -3.5, Winner -179
Panthers Spread +3.5, Winner +139

Oct 12 – Totals O/U 43
Chargers Spread -4, Winner -222
Dolphins Spread +4, Winner +170

Oct 12 – Totals O/U 46
Patriots Spread -3.5, Winner -196
Saints Spread +3.5, Winner +151

Oct 12 – Totals O/U 41
Titans Spread +4.5, Winner +177
Raiders Spread -4.5, Winner -232

Oct 12 – Totals O/U 47.5
49ers Spread +3, Winner +125
Buccaneers Spread -3, Winner -160

Oct 12 – Totals O/U 44.5
Bengals Spread +14.5, Winner +788
Packers Spread -14.5, Winner -1683

Oct 12 – Totals O/U 52.5
Lions Spread +2, Winner +112
Chiefs Spread -2, Winner -142

Oct 13 – Totals O/U 49.5
Bills Spread -4.5, Winner -216
Falcons Spread +4.5, Winner +166

Oct 13 – Totals O/U 49
Bears Spread +4.5, Winner +171
Commanders Spread -4.5, Winner -224

 

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About the Author

MyBookie's Expert Writer
  • D.S. Williamson
  • Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.