Explore the NFL top betting Week 6 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Six
Top NFL Week 6 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 6: Thursday, October 9th – Monday, October 13th, 2025
BYE WEEK: Texans, Vikings
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NFL Football Lines Week Six
Betting 2025 NFL Week 6 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Oct. 9, 8:15 PM EDT | Eagles at Giants | Eagles TBA; Giants TBA | TBA |
| Sun, Oct. 12, 9:30 AM EDT | Broncos vs Jets | Broncos TBA; Jets TBA | TBA |
| Sun, Oct. 12, 1:00 PM EDT | Rams at Ravens | Rams TBA; Ravens TBA | TBA |
| Sun. Oct. 12, 1:00 PM EDT | Cowboys at Panthers | Cowboys TBA; Panthers TBA | TBA |
| Sun, Oct. 12, 1:00 PM EDT | Cardinals at Colts | Cardinals TBA; Colts TBA | TBA |
| Sun. Oct. 12, 1:00 PM EDT | Seahawks at Jaguars | Seahawks TBA; Jaguars TBA | TBA |
| Sun, Oct. 12, 1:00 PM EDT | Chargers at Dolphins | Chargers TBA; Dolphins TBA | TBA |
| Sun. Oct. 12, 1:00 PM EDT | Browns at Steelers | Browns TBA; Steelers TBA | TBA |
| Sun, Oct. 12, 1:00 PM EDT | 49ers at Buccaneers | 49ers TBA; Buccaneers TBA | TBA |
| Sun. Oct. 12, 4:05 PM EDT | Titans at Raiders | Titans TBA; Raiders TBA | TBA |
| Sun, Oct. 12, 4:25 PM EDT | Bengals at Packers | Bengals TBA; Packers TBA | TBA |
| Sun. Oct. 12, 4:25 PM EDT | Patriots at Saints | Patriots TBA; Saints TBA | TBA |
| Sun, Oct. 12, 8:20 PM EDT | Lions at Chiefs | Lions TBA; Chiefs TBA | TBA |
| Mon. Oct. 13, 7:15 PM EDT | Bills at Falcons | Bills TBA; Falcons TBA | TBA |
| Mon. Oct. 13, 8:15 PM EDT | Bears at Commanders | Bears TBA; Commanders TBA | TBA |
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
