Explore the NFL top betting Week 10 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Ten
Top NFL Week 10 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 10: Thursday, November 6th – Monday, November 10th, 2025
BYE WEEK: Bengals, Cowboys, Chiefs, Titans
Key Games to Watch and Bet
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NFL Football Lines Week Ten
Betting 2025 NFL Week 10 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Nov 6 – Totals TBA
Raiders Spread TBA, Winner TBA
Broncos Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Falcons Spread TBA, Winner TBA
Cowboys Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Saints Spread TBA, Winner TBA
Panthers Spread TBA, Winner TBA
Nov 9 – Totals TBA
Giants Spread TBA, Winner TBA
Bears Spread TBA, Winner TBA
Nov 9 – Totals TBA
Jaguars Spread TBA, Winner TBA
Texans Spread TBA, Winner TBA
Nov 9 – Totals TBA
Bills Spread TBA, Winner TBA
Dolphins Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
49ers Spread TBA, Winner TBA
Giants Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Colts Spread TBA, Winner TBA
Steelers Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Chargers Spread TBA, Winner TBA
Titans Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Saints Spread TBA, Winner TBA
Rams Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Jaguars Spread TBA, Winner TBA
Raiders Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Chiefs Spread TBA, Winner TBA
Bills Spread TBA, Winner TBA
Nov 9 – Totals O/U TBA
Seahawks Spread TBA, Winner TBA
Commanders Spread TBA, Winner TBA
Nov 10 – Totals O/U TBA
Cardinals Spread TBA, Winner TBA
Cowboys Spread TBA, Winner TBA
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
