Explore the NFL top betting Week 10 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Ten
Top NFL Week 10 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 10: Thursday, November 6th – Monday, November 10th, 2025
BYE WEEK: Bengals, Cowboys, Chiefs, Titans
Key Games to Watch and Bet
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NFL Football Lines Week Ten
Betting 2025 NFL Week 10 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu. Nov. 6, 8:15 PM EST | Raiders at Broncos | Raiders TBA; Broncos TBA | TBA |
| Sun, Nov. 9, 9:30 AM EST | Falcons vs Cowboys | Falcons TBA; Cowboys TBA | TBA |
| Sun. Nov. 9, 1:00 PM EST | Saints at Panthers | Saints TBA; Panthers TBA | TBA |
| Sun, Nov. 9, 1:00 PM EST | Giants at Bears | Giants TBA; Bears TBA | TBA |
| Sun. Nov. 9, 1:00 PM EST | Jaguars at Texans | Jaguars TBA; Texans TBA | TBA |
| Sun, Nov. 9, 1:00 PM EST | Bills at Dolphins | Bills TBA; Dolphins TBA | TBA |
| Sun. Nov. 9, 1:00 PM EST | 49ers at Giants | 49ers TBA; Giants TBA | TBA |
| Sun, Nov. 9, 1:00 PM EST | Colts at Steelers | Colts TBA; Steelers TBA | TBA |
| Sun. Nov. 9, 1:00 PM EST | Chargers at Titans | Chargers TBA; Titans TBA | TBA |
| Sun, Nov. 9, 4:05 PM EST | Saints at Rams | Saints TBA; Rams TBA | TBA |
| Sun. Nov. 9, 4:25 PM EST | Jaguars at Raiders | Jaguars TBA; Raiders TBA | TBA |
| Sun, Nov. 9, 4:25 PM EST | Chiefs at Bills | Chiefs TBA; Bills TBA | TBA |
| Sun. Nov. 9, 8:20 PM EST | Seahawks at Commanders | Seahawks TBA; Commanders TBA | TBA |
| Mon. Nov. 10, 8:15 PM EST | Cardinals at Cowboys | Cardinals TBA; Cowboys TBA | TBA |
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
