Explore the NFL top betting Week 12 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Twelve
Top NFL Week 12 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 12: Thursday, November 20th – Monday, November 24th, 2025
BYE WEEK: Broncos, Chargers, Dolphins, Commanders
Key Games to Watch and Bet
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NFL Football Lines Week Twelve
Betting 2025 NFL Week 12 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Nov. 20, 8:15 PM EST | Bills at Texans | Bills TBA; Texans TBA | TBA |
| Sun. Nov. 23, 1:00 PM EST | Jets vs Ravens | Jets TBA; Ravens TBA | TBA |
| Sun, Nov. 23, 1:00 PM EST | Steelers at Bears | Steelers TBA; Bears TBA | TBA |
| Sun. Nov. 23, 1:00 PM EST | Patriots at Bengals | Patriots TBA; Bengals TBA | TBA |
| Sun. Nov. 23, 1:00 PM EST | Giants at Lions | Giants TBA; Lions TBA | TBA |
| Sun, Nov. 23, 1:00 PM EST | Vikings at Packers | Vikings TBA; Packers TBA | TBA |
| Sun. Nov. 23, 1:00 PM EST | Colts at Chiefs | Colts TBA; Chiefs TBA | TBA |
| Sun, Nov. 23, 1:00 PM EST | Seahawks at Titans | Seahawks TBA; Titans TBA | TBA |
| Sun. Nov. 23, 4:05 PM EST | Jaguars at Cardinals | Jaguars TBA; Cardinals TBA | TBA |
| Sun, Nov. 23, 4:05 PM EST | Browns at Raiders | Browns TBA; Raiders TBA | TBA |
| Sun. Nov. 23, 4:25 PM EST | Eagles at Cowboys | Eagles TBA; Cowboys TBA | TBA |
| Sun, Nov. 23, 4:25 PM EST | Falcons at Saints | Falcons TBA; Saints TBA | TBA |
| Sun. Nov. 23, 8:20 PM EST | Buccaneers at Rams | Buccaneers TBA; Rams TBA | TBA |
| Mon. Nov. 24, 8:15 PM EST | Panthers at 49ers | Panthers TBA; 49ers TBA | TBA |
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
