Get your NFL top betting Week 12 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Twelve
Top NFL Week 12 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 12: Thursday, November 20th – Monday, November 24th, 2025
BYE WEEK: Broncos, Chargers, Dolphins, Commanders
Key Games to Watch and Bet
So, what are you waiting for?
Head over to our NFL betting lines now and Sign Up for an Account to bet on all the matchups of Week 12 and the rest of the season, you’re sure to find the perfect wager to add some extra excitement to your NFL viewing experience!
NFL Football Lines Week Twelve
Betting 2025 NFL Week 12 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Nov 20 – Totals 43.5
Bills Spread -6, Winner -294
Texans Spread +6, Winner +232
Nov 23 – Totals O/U 44.5
Jets Spread +13.5, Winner +590
Ravens Spread -13.5, Winner -1099
Nov 23 – Totals O/U 45
Steelers Spread +3, Winner +116
Bears Spread -3, Winner -148
Nov 23 – Totals 49.5
Patriots Spread -9, Winner -459
Bengals Spread +9, Winner +324
Nov 23 – Totals O/U 50
Colts Spread +3.5, Winner +144
Chiefs Spread -3.5, Winner -186
Nov 23 – Totals 41
Vikings Spread +6.5, Winner +232
Packers Spread -6.5, Winner -310
Nov 23 – Totals O/U 40.5
Seahawks Spread -13, Winner -1099
Titans Spread +13, Winner +610
Nov 23 – Totals 50.5
Giants Spread +10.5, Winner +390
Lions Spread -10.5, Winner -599
Nov 23 – Totals O/U 36.5
Browns Spread +3.5, Winner +150
Raiders Spread -3.5, Winner -194
Nov 23 – Totals O/U 47.5
Jaguars Spread -2.5, Winner -161
Cardinals Spread +2.5, Winner +127
Nov 23 – Totals O/U 47.5
Eagles Spread -3.5, Winner -184
Cowboys Spread +3.5, Winner +142
Nov 23 – Totals O/U 39.5
Falcons Spread +2, Winner +101
Saints Spread -2, Winner -129
Nov 23 – Totals O/U 49.5
Buccaneers Spread +6.5, Winner +228
Rams Spread -6.5, Winner -310
Nov 24 – Totals O/U 49
Panthers Spread +6.5, Winner +271
49ers Spread -6.5, Winner -381
<< Week Eleven
Elevate your NFL Season with MyBookie + Loyalty Rewards Program
Start to earn points with the Sportsbook and Casino Loyalty Program to level up, get exclusive bonuses and rakeback in every stage of the 2025/26 Season: Draft, Offseason, Preseason, Regular Season, Playoffs and Super Bowl.
Join the MyBookie program, subscribing will guarantee your share of $15,000 in free plays.
Bet On NFL top betting odds, anywhere, anytime
Complement your plans with our NFL betting insights and everything you need to know for the season that brings you higher opportunities to win in all Divisions, Conferences and the Super Bowl.
NFL Betting
All NFL Teams Betting Lines, Futures & Odds with MyBookie
AFC Division Betting Odds
Welcome Bonuses from MyBookie : DOUBLE YOUR FIRST CRYPTO DEPOSIT!
About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
