Get your NFL top betting Week 12 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Twelve
Top NFL Week 12 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 12: Thursday, November 20th – Monday, November 24th, 2025
BYE WEEK: Broncos, Chargers, Dolphins, Commanders
Key Games to Watch and Bet
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NFL Football Lines Week Twelve
Betting 2025 NFL Week 12 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Nov 20 – Totals TBA
Bills Spread TBA, Winner TBA
Texans Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Jets Spread TBA, Winner TBA
Ravens Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Steelers Spread TBA, Winner TBA
Bears Spread TBA, Winner TBA
Nov 23 – Totals TBA
Patriots Spread TBA, Winner TBA
Bengals Spread TBA, Winner TBA
Nov 23 – Totals TBA
Giants Spread TBA, Winner TBA
Lions Spread TBA, Winner TBA
Nov 23 – Totals TBA
Vikings Spread TBA, Winner TBA
Packers Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Colts Spread TBA, Winner TBA
Chiefs Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Seahawks Spread TBA, Winner TBA
Titans Spread TBA, Winner TBA
Nov 23 – Totals O/U 48.236
Jaguars Spread TBA, Winner TBA
Cardinals Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Browns Spread TBA, Winner TBA
Raiders Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Eagles Spread TBA, Winner TBA
Cowboys Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Falcons Spread TBA, Winner TBA
Saints Spread TBA, Winner TBA
Nov 23 – Totals O/U TBA
Buccaneers Spread TBA, Winner TBA
Rams Spread TBA, Winner TBA
Nov 24 – Totals O/U TBA
Panthers Spread TBA, Winner TBA
49ers Spread TBA, Winner TBA
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
