Explore the NFL top betting Week 1 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week One
Top NFL Week 1 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 1: Thursday, September 4th – Monday, September 8th, 2025
BYE WEEK: No teams on bye
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NFL Football Lines Week One
Betting 2025 NFL Week 1 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Sept. 4, 8:20 PM EDT | Cowboys at Eagles -7 | Cowboys +242; Eagles -330 | 46.5 |
| Fri, Sept. 5, 8:00 PM EDT | Chiefs vs Chargers -2.5 | Chiefs +100; Chargers -127 | 44.5 |
| Sun, Sept. 7, 1:00 PM EDT | Buccaneers -2.5 at Falcons | Buccaneers -142; Falcons +111 | 49 |
| Sun. Sept. 7, 1:00 PM EDT | Bengals -5.5 at Browns | Bengals -250; Browns +189 | 46 |
| Sun, Sept. 7, 1:00 PM EDT | Dolphins -1 at Colts | Dolphins -103; Colts -123 | 46 |
| Sun. Sept. 7, 1:00 PM EDT | Panthers at Jaguars -2.5 | Panthers +130; Jaguars -167 | 46 |
| Sun, Sept. 7, 1:00 PM EDT | Raiders at Patriots -3 | Raiders +129; Patriots -166 | 43.5 |
| Sun. Sept. 7, 1:00 PM EDT | Cardinals -5 at Saints | Cardinals -222; Saints +170 | 41.5 |
| Sun, Sept. 7, 1:00 PM EDT | Steelers -3 at Jets | Steelers -154; Jets +120 | 39 |
| Sun. Sept. 7, 1:00 PM EDT | Giants at Commanders -6.5 | Giants +228; Commanders -310 | 45 |
| Sun, Sept. 7, 4:05 PM EDT | Titans at Broncos -7.5 | Titans +275; Broncos -391 | 42 |
| Sun. Sept. 7, 4:05 PM EDT | 49ers -2 at Seahawks | 49ers -128; Seahawks +101 | 45.5 |
| Sun, Sept. 7, 4:25 PM EDT | Lions at Packers -1 | Lions -106; Packers -120 | 49.5 |
| Sun. Sept. 7, 4:25 PM EDT | Texans at Rams -3 | Texans +123; Rams -158 | 41 |
| Sun, Sept. 7, 8:20 PM EDT | Ravens at Bills -1 | Ravens -101; Bills -127 | 51 |
| Mon, Sept. 8, 8:15 PM EDT | Vikings at Bears -1.5 | Vikings -103; Bears -123 | 45 |
NFL Week Two >>
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
