Explore the NFL top betting Week 4 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Four
Top NFL Week 4 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 4: Thursday, September 25th – Monday, September 29th, 2025
BYE WEEK: No teams on bye
Must-Watch Matchups to Secure your Bets
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NFL Football Lines Week Four
Betting 2025 NFL Week 4 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Sept. 25, 8:15 PM EDT | Seahawks at Cardinals | Dolphins TBA; Bills TBA | TBA |
| Sun, Sept. 28, 9:30 AM EDT | Vikings at Steelers | Vikings TBA; Steelers TBA | TBA |
| Sun, Sept. 28, 1:00 PM EDT | Commanders at Falcons | Commanders TBA; Falcons TBA | TBA |
| Sun. Sept. 28, 1:00 PM EDT | Saints at Bills | Saints TBA; Bills TBA | TBA |
| Sun, Sept. 28, 1:00 PM EDT | Browns at Lions | Browns TBA; Lions TBA | TBA |
| Sun. Sept. 28, 1:00 PM EDT | Titans at Texans | Titans TBA; Texans TBA | TBA |
| Sun, Sept. 28, 1:00 PM EDT | Panthers at Patriots | Panthers TBA; Patriots TBA | TBA |
| Sun. Sept. 28, 1:00 PM EDT | Chargers at Giants | Chargers TBA; Giants TBA | TBA |
| Sun, Sept. 28, 1:00 PM EDT | Eagles at Buccaneers | Eagles TBA; Buccaneers TBA | TBA |
| Sun. Sept. 28, 4:05 PM EDT | Colts at Rams | Colts TBA; Rams TBA | TBA |
| Sun, Sept. 28, 4:05 PM EDT | Jaguars at 49ers | Jaguars TBA; 49ers TBA | TBA |
| Sun. Sept. 28, 4:25 PM EDT | Ravens at Chiefs | Ravens TBA; Chiefs TBA | TBA |
| Sun, Sept. 28, 4:25 PM EDT | Bears at Raiders | Bears TBA; Raiders TBA | TBA |
| Sun. Sept. 28, 8:20 PM EDT | Packers at Cowboys | Packers TBA; Cowboys TBA | TBA |
| Mon, Sept. 29, 7:15 PM EDT | Jets at Dolphins | Jets TBA; Dolphins TBA | TBA |
| Mon, Sept. 29, 8:15 PM EDT | Bengals at Broncos | Bengals TBA; Broncos TBA | TBA |
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
