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NFL Football Lines Week Three
Top NFL Week 3 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 3: Thursday, September 18th – Monday, September 22nd, 2025
BYE WEEK: No teams on bye
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NFL Football Lines Week Three
Betting 2025 NFL Week 3 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Sept. 18, 8:15 PM EDT | Dolphins at Bills | Dolphins TBA; Bills TBA | TBA |
| Sun, Sept. 21, 1:00 PM EDT | Falcons at Panthers | Falcons TBA; Panthers TBA | TBA |
| Sun, Sept. 21, 1:00 PM EDT | Packers at Browns | Packers TBA; Browns TBA | TBA |
| Sun. Sept. 21, 1:00 PM EDT | Texans at Jaguars | Texans TBA; Jaguars TBA | TBA |
| Sun, Sept. 21, 1:00 PM EDT | Bengals at Vikings | Bengals TBA; Vikings TBA | TBA |
| Sun. Sept. 21, 1:00 PM EDT | Steelers at Patriots | Steelers TBA; Patriots TBA | TBA |
| Sun, Sept. 21, 1:00 PM EDT | Rams at Eagles | Rams TBA; Eagles TBA | TBA |
| Sun. Sept. 21, 1:00 PM EDT | Jets at Buccaneers | Jets TBA; Buccaneers TBA | TBA |
| Sun, Sept. 21, 1:00 PM EDT | Colts at Titans | Colts TBA; Titans TBA | TBA |
| Sun. Sept. 21, 1:00 PM EDT | Raiders at Commanders | Raiders TBA; Commanders TBA | TBA |
| Sun, Sept. 21, 4:05 PM EDT | Broncos at Chargers | Broncos TBA; Chargers TBA | TBA |
| Sun. Sept. 21, 4:05 PM EDT | Saints at Seahawks | Saints TBA; Seahawks TBA | TBA |
| Sun, Sept. 21, 4:25 PM EDT | Cowboys at Bears | Cowboys TBA; Bears TBA | TBA |
| Sun. Sept. 21, 4:25 PM EDT | Cardinals at 49ers | Cardinals TBA; 49ers TBA | TBA |
| Sun, Sept. 21, 8:20 PM EDT | Chiefs at Giants | Chiefs TBA; Giants TBA | TBA |
| Mon, Sept. 22, 8:15 PM EDT | Lions at Ravens | Lions TBA; Ravens TBA | TBA |
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
