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NFL Football Lines Week Two
Top NFL Week 2 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 2: Thursday, September 11th – Monday, September 15th, 2025
BYE WEEK: No teams on bye
Find Out Which Teams Are Primed for a Surprise!
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NFL Football Lines Week Two
Betting 2025 NFL Week 2 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Sept. 11, 8:15 PM EDT | Commanders at Packers -1.5 | Commanders +102; Packers -129 | 48.5 |
| Sun, Sept. 14, 1:00 PM EDT | Browns at Ravens -12.5 | Browns +430; Ravens -676 | 44.5 |
| Sun, Sept. 14, 1:00 PM EDT | Jaguars at Bengals -5.5 | Jaguars +178; Bengals -234 | 49.5 |
| Sun. Sept. 14, 1:00 PM EDT | Giants at Cowboys -4.5 | Giants +150; Cowboys -194 | 44.5 |
| Sun, Sept. 14, 1:00 PM EDT | Bears at Lions -4.5 | Bears +173; Lions -226 | 48.5 |
| Sun. Sept. 14, 1:00 PM EDT | Patriots at Dolphins -2.5 | Patriots +119; Dolphins -152 | 45.5 |
| Sun, Sept. 14, 1:00 PM EDT | 49ers at Saints | 49ers TBA; Saints TBA | TBA |
| Sun. Sept. 14, 1:00 PM EDT | Bills at Jets | Bills TBA; Jets TBA | TBA |
| Sun, Sept. 14, 1:00 PM EDT | Seahawks at Steelers | Seahawks TBA; Steelers TBA | TBA |
| Sun. Sept. 14, 1:00 PM EDT | Rams at Titans | Rams TBA; Titans TBA | TBA |
| Sun, Sept. 14, 4:05 PM EDT | Panthers at Cardinals | Panthers TBA; Cardinals TBA | TBA |
| Sun. Sept. 14, 4:05 PM EDT | Broncos at Colts | Broncos TBA; Colts TBA | TBA |
| Sun, Sept. 14, 4:25 PM EDT | Eagles at Chiefs | Eagles TBA; Chiefs TBA | TBA |
| Sun. Sept. 14, 8:20 PM EDT | Falcons at Vikings | Falcons TBA; Vikings TBA | TBA |
| Mon, Sept. 15, 7:00 PM EDT | Buccaneers at Texans | Buccaneers TBA; Texans TBA | TBA |
| Mon, Sept. 15, 10:00 PM EDT | Chargers at Raiders | Chargers TBA; Raiders TBA | TBA |
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
