Check out the NFL top betting Week 2 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
This week, pay attention to our expert’s analysis related to the props, including the stat you’re ignoring that will wreck your favorite Running Back prop bet.
NFL Football Lines Week Two
Top NFL Week 2 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 2: Thursday, September 11th – Monday, September 15th, 2025
BYE WEEK: No teams on bye
Find Out Which Teams Are Primed for a Surprise!
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Head over to our NFL betting lines now and Sign Up for an Account to bet on all the matchups of Week 2 and the rest of the season, you’re sure to find the perfect wager to add some extra excitement to your NFL viewing experience!
NFL Football Lines Week Two
Betting 2025 NFL Week 2 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Sep 11 – Totals O/U 48
Packers Spread -3.5, Winner -178
Commanders Spread +3.5, Winner +144
Sep 14 – Totals O/U 45
Ravens Spread -11.5, Winner -1019
Browns Spread +11.5, Winner +584
Sep 14 – Totals O/U 49
Bengals Spread -3.5, Winner -187
Jaguars Spread +3.5, Winner +151
Sep 14 – Totals O/U 44.5
Cowboys Spread -5, Winner -238
Giants Spread +5, Winner +189
Sep 14 – Totals O/U 46.5
Lions Spread -6, Winner -272
Bears Spread +6, Winner +215
Sep 14 – Totals O/U 43
Dolphins Spread -1, Winner -118
Patriots Spread +1, Winner -104
Sep 14 – Totals O/U 42
Titans Spread +5.5, Winner +200
Rams Spread -5.5, Winner -250
Sep 14 – Totals O/U 40
Steelers Spread -3, Winner -166
Seahawks Spread +3, Winner +135
Sep 14 – Totals O/U 40.5
Saints Spread +3, Winner +138
49ers Spread -3, Winner -170
Sep 14 – Totals O/U 46.5
Jets Spread +6.5, Winner +238
Bills Spread -6.5, Winner -309
Sep 14 – Totals O/U 44
Cardinals Spread -6.5, Winner -300
Panthers Spread +6.5, Winner +234
Sep 14 – Totals O/U 42.5
Colts Spread +1.5, Winner -101
Broncos Spread -1.5, Winner -121
Sep 14 – Totals O/U 47
Chiefs Spread +1, Winner -103
Eagles Spread -1, Winner -120
Sep 14 – Totals O/U 44.5
Vikings Spread -3.5, Winner -199
Falcons Spread +3.5, Winner +160
Sep 15 – Totals O/U 42.5
Texans Spread -2.5, Winner -144
Buccaneers Spread +2.5, Winner +117
Sep 15 – Totals O/U 46.5
Raiders Spread +3.5, Winner +149
Chargers Spread -3.5, Winner -185
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
