Check out the NFL top betting Week 2 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Two
Top NFL Week 2 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 2: Thursday, September 11th – Monday, September 15th, 2025
BYE WEEK: No teams on bye
Find Out Which Teams Are Primed for a Surprise!
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NFL Football Lines Week Two
Betting 2025 NFL Week 2 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Sep 4 – Totals O/U 46.5
Eagles Spread -7, Winner -340
Cowboys Spread +7, Winner +250
Sep 5 – Totals O/U 45.5
Chargers Spread +3, Winner +127
Chiefs Spread -3, Winner -162
Sep 7 – Totals O/U 46.5
Colts Spread -1, Winner -118
Dolphins Spread +1, Winner -108
Sep 7 – Totals O/U 38.5
Jets Spread +3, Winner +128
Steelers Spread -3, Winner -164
Sep 7 – Totals O/U 45.5
Commanders Spread -6.5, Winner -300
Giants Spread +6.5, Winner +222
Sep 7 – Totals O/U 48.5
Falcons Spread +1.5, Winner +103
Buccaneers Spread -1.5, Winner -132
Sep 7 – Totals O/U 42.5
Saints Spread +5.5, Winner +200
Cardinals Spread -5.5, Winner -265
Sep 7 – Totals O/U 45
Browns Spread +5.5, Winner +186
Bengals Spread -5.5, Winner -246
Sep 7 – Totals O/U 46
Jaguars Spread -2.5, Winner -156
Panthers Spread +2.5, Winner +122
Sep 7 – Totals O/U 42.5
Patriots Spread TBA, Winner -165
Raiders Spread TBA, Winner +129
Sep 7 – Totals O/U 41.5
Broncos Spread -7.5, Winner -429
Titans Spread +7.5, Winner +300
Sep 7 – Totals O/U 45
Seahawks Spread +2.5, Winner +109
49ers Spread -2.5, Winner -139
Sep 7 – Totals O/U 45
Rams Spread -2.5, Winner -145
Texans Spread +2.5, Winner +113
Sep 7 – Totals O/U 49.5
Packers Spread -2, Winner -129
Lions Spread +2, Winner +101
Sep 7 – Totals O/U 52
Bills Spread -1, Winner -120
Ravens Spread +1, Winner -106
Sep 8 – Totals O/U 43
Bears Spread +1.5, Winner +103
Vikings Spread -1.5, Winner -131
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
