FIFA World Cup Qualifying in South American CONMENBOL continues Tuesday. Bolivia is a massive home dog versus Argentina, Ecuador is a favorite against Uruguay, and Venezuela and Paraguay should be competitive.

Oddsmakers also believe Chile hosting Colombia will be a competitive match. The one handicap favorite on Tuesday is Brazil against Peru.

Check out World Cup odds, analysis, and free picks for the three CONMEBOL matches taking place on Tuesday, September 12.

2026 FIFA World Cup CONMEBOL Qualifiers: Matchday 2 Betting Analysis | MyBookie World Cup Preview

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CONMEBOL Qualifiers Matchday 2: Tuesday, September 12th, 2023

Bolivia vs Argentina | Matchday 2

CONMEBOL Odds: Bolivia +0.5; Argentina -0.5 / Bolivia +460; Argentina -170; Draw +310 / O/U 2.5
Tuesday, Sep 12 at 4:00 pm ET
Estadio Hernando Siles, La Paz, Bolivia

In the last match between Bolivia and Argentina, in September 2021, the Argentinians blasted Bolivia 3-0. The Albiceleste is much different now than they were then, which is why we can back Argentina at decent -166 odds.

Home squad Bolivia has 3 losses and a draw in their last 4. In their first FIFA WC qualifier, Brazil dominated the Bolivians 5-1. It’s tough seeing Bolivia bouncing back. Argentina, who beat Ecuador 1-0 in their first WC qualifier, is the pick.

FIFA World Cup Qualifying CONMEBOL Pick: Argentina | Bet Bolivia vs Argentina
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Ecuador vs Uruguay | Matchday 2

CONMEBOL Odds: Ecuador -0.5; Uruguay +0.5 / Ecuador -110; Uruguay +330; Draw +240 / O/U 2.5
Tuesday, Sep 12 at 5:00 pm ET
Estadio Rodrigo Paz Delgado, Quito, Ecuador

Ecuador is a massive favorite. On one hand, it makes sense. Ecuador played great soccer versus Argentina in a 1-0 loss in their last.

But on the other hand, it makes no sense. Uruguay is on a nice 4-match winning streak. If we go back 5 matches, Uruguay drew 1-1 against Japan in an international friendly. So the Uruguayans are in terrific form. Although Ecuador should win this, we can’t look past Uruguay’s odds. 

FIFA World Cup Qualifying CONMEBOL Pick: Uruguay | Bet Ecuador vs Uruguay
MyBookie Betting Lines for the Game

Venezuela vs Paraguay | Matchday 2

CONMEBOL Odds: Venezuela +0.5; Paraguay -0.5 / Venezuela +162; Paraguay +188; Draw +212 / O/U 2.5
Tuesday, Sep 12 at 6:00 pm ET
Estadio Monumental, Maturín, Venezuela

Venezuela versus Paraguay should be an exceptional match. Both teams played well in their first FIFA World Cup Qualifying contest. Venezuela lost to Colombia via a 1-0 score.

Paraguay drew 0-0 against Peru. Paraguay has won the last couple of head-to-head matchups. But the games happened in 2020 and 2021. Venezuela is a much different team now than they were then.

The Venezuelans take on their rivals on their pitch in Maturin. For sure, Venezuela will be fired up. At the end, though, Paraguay is the slightly better squad. The road team forces a draw.

FIFA World Cup Qualifying CONMEBOL Pick: Draw | Bet Venezuela vs Paraguay
MyBookie Betting Lines for the Game

Chile vs Colombia | Matchday 2

CONMEBOL Odds: Chile +0.5; Colombia -0.5 / Chile +184; Colombia +165; Draw +212 / O/U 2.5
Tuesday, Sep 12 at 8:30 pm ET
Estadio Monumental David Arellano, Santiago, Chile

The home team dog in this, Chile, shows 3 wins, a draw and a loss in their last 5. The reason Colombia is the favorite is because Chile’s 3 victories came in international friendly matches.

Outside of the international friendlies, Chile drew against Bolivia and lost to Uruguay 3-1 on Sep 8. Colombia isn’t dominating, but they have won 4 straight. The road team plays well enough for a victory.

FIFA World Cup Qualifying CONMEBOL Pick: Colombia | Bet Chile vs Colombia
MyBookie Betting Lines for the Game

Peru vs Brazil | Matchday 2

CONMEBOL Odds: Peru +1.5; Brazil -1.5 / Peru +800; Brazil -294; Draw +420 / O/U 2.5
Tuesday, Sep 12 at 10:00 pm ET
Estadio Nacional, Lima, Peru

It’s been a while since Brazil sent a team to the pitch that had the talent and was cohesive enough to win the World Cup. While leaning on players like Neymar and Raphinha, Brazil hopes to develop their young stars by the time the World Cup cycle returns.

Brazil blasted Bolivia 5-1 in their first WC qualifier. The Brazilians should win this by at least 2 and a 3 goal victory is possible.  

FIFA World Cup Qualifying CONMEBOL Pick: Brazil -1.5 | Bet Peru vs Brazil
MyBookie Betting Lines for the Game

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