San Francisco 49ers Betting: Top Odds and Insights | MyBookie

San Francisco 49ers Standings – How the 49ers Stand in the Odds to Win with MyBookie

The 49ers this 2025 Season 0-0 4th NFC West. Games odds, spreads, totals, stats, schedule, futures.

Odds subject to change every week. Last Updated: June 2nd.

• Current NFC Conference Standings: 12th
• +155 to win NFC West
• +730 to win NFC Conference
• +1800 to win Super Bowl

49ers NFL Calendar 2025

• at Seattle Seahawks, Week 1 – Sun 09/07 · 1:05 PM PDT
• at New Orleans Saints, Week 2 – Sun 09/14 · 10:00 AM PDT
• vs Arizona Cardinals, Week 3 – Sun 09/21 · 1:25 PM PDT
• vs Jacksonville Jaguars, Week 4 – Sun 09/28 · 1:05 PM PDT
• at Los Angeles Rams, Week 5 – TNF 10/02 · 5:15 PM PDT
• at Tampa Bay Buccaneers, Week 6 – Sun 10/12 · 10:00 AM PDT
• vs Atlanta Falcons, Week 7 – SNF 10/19 · 5:20 PM PDT
• at Houston Texans, Week 8 – Sun 10/26 · 10:00 AM PDT
• at New York Giants, Week 9 – Sun 11/02 · 10:00 AM PST
• vs Los Angeles Rams, Week 10 – Sun 11/09 · 1:25 PM PST
• at Arizona Cardinals, Week 11 – Sun 11/16 · 1:05 PM PST
• vs Carolina Panthers, Week 12 – MNF 11/24 · 5:15 PM PST
• at Cleveland Browns, Week 13 – Sun 11/30 · 10:00 AM PST
• BYE, Week 14
• vs Tennessee Titans, Week 15 – Sun 12/14 · 1:25 PM PST
• at Indianapolis Colts, Week 16 – SNF 12/21 · 5:15 PM PST
• vs Chicago Bears, Week 17 – SNF 12/28· 5:20 PM PST
• vs Seattle Seahawks, Week 18 – TBD

Looking to maximize your bets on the San Francisco 49ers? We’ve got all the tools you need, from 49ers lines to the latest 49ers odds, ensuring you stay ahead in your betting strategy.

Whether you’re looking to bet against the spread or explore other betting opportunities, our expert analysis has you covered.

National Football League | West Division
Levi’s Stadium

Best 49ers Games to Bet On

If we are going to talk about the 49ers top games to bet on, it has to be their rivalry matches during the season.

49ers vs Seahawks Rivalry

Expect a defensive chess match or a potential offensive explosion. Analyze the 49ers Seahawks betting lines as you consider a moneyline bet on the underdog, or analyze the point spread to find a strategic bet.

Look at under/over point totals or interceptions for the 49ers’ secondary. Also, consider prop bets on passing yards for the Seahawks’ quarterback or rushing yards for their star running back.

49ers vs Rams Rivalry

This in-state rivalry is s a heated battle for NFC West dominance, plus you add the fact that they are also divisional foes.

Each matchup between these two powerhouses will often have major playoff implications. As, it pits the 49ers’ physical defense against the Rams’ well-rounded offense.

Analyze the 49ers Rams betting lines as you consider a moneyline bet on the underdog, or analyze the point spread to find a strategic bet.

Remember the NFL Props, look for exciting prop bets on sacks by the 49ers’ defensive line or receiving yards for the Rams’ star wideouts.

49ers Packers Rivalry

The rivalry between the 49ers and Packers has developed into one of the NFL’s premier matchups in recent years, particularly in the postseason.

San Francisco 49ers Odds

Bet the latest NFL daily lines for the 49ers, NFC West standings, plus betting news on the Niners.

Remember, MyBookie has the Football odds along with 1st half lines and 2nd half bets for each game throughout the Regular Season and Postseason, reaching all the way to the next Super Bowl.

Create Your MyBookie Account

It’s very easy to Join us and win with San Francisco, first, go to our Sign-up page, then, you’ll be able to create an account with MyBookie.

Second, explore our betting lines and props for the San Francisco 49ers.

Additionally, you can start to materialize your betting plans with the options that MyBookie has for you, such as Credit Card or PayPal.

Print San Francisco 49ers Odds

Unleash the power of the Red and Gold with our comprehensive coverage on their upcoming games, plus futures odds for the San Francisco’s Super Bowl run.

From breaking news and analysis of the team’s performance to the latest NFL rumors and the updated betting odds for each match and the odds to win in the NFL season.

We provide all the information you need to make that bet on one of the NFC’s most dynamic franchises.